… next-generation RAF inhibitors with enhanced therapeutic profiles. … between RAF-targeted
therapies and autophagy in cancer. … , such as MEK and ERK, in the MAPK signaling pathway. …

… selective MAPK inhibitors in clinical trials. We also review the potential of RAF1 as a key
target … RAS proteins activate a plethora of signaling pathways by direct engagement of effector …

… The MAPK pathway also integrates signals from complex … the core elements of the
MAPK pathways nearly four decades ago, … dominant cancer signaling pathway: RAS/RAF/MEK/ERK. …

… pathways, RAS–RAF–MEK–ERK and RAS–PI3K-AKT–mTORC, act as fundamental signaling
pathways of RAS … the downstream RAS–RAF–MEK–ERK pathway, promoting MAPK signal …

… in 1993 [12, 13], resulting in the delineation of the whole MAPK signaling pathway, which
is considered as a milestone in our understanding of how cell senses external stimuli. …

… , we reviewed marine compounds targeting the MAPK signaling pathway for cancer treatment.
The … 2) targeting the MAPK signaling pathway in 11 common cancers. These 32 marine …

… MAPK signaling pathway, pointing to the possibility of exploiting iron chelators as a novel …
/ERK5 signaling molecules are emerging as additional possible targets for cancer therapy [9]. …

… (MAPKs) that facilitate the culmination of signal transduction … and RAF/MEK/ERK signaling
pathways in carcinoma initiation … therapy, summarizing the recent doubts about targeting the …

… that target the MAPK-signaling pathway in cancer therapy. … products targeting MAPK-signaling
pathways in cancer has … and the role of the MAPK pathway in various cancers, as well …

… to targeting the signaling pathway for cancer treatment in the … of inhibitors targeting the
RAS–RAF–MEK–ERK pathway with … scaffold in the RAS/MAPK pathway for bridging MEK to RAF. …