Fibroblast growth factor receptor signalling dysregulation and targeting in breast cancer
C Francavilla, CS O'Brien - Open Biology, 2022 - royalsocietypublishing.org
… complex Fibroblast Growth Factor Receptor (FGFR) family, … target for drug development in
breast cancer, we will outline clinical trial data on the use of FGFR-targeted therapies in cancer …
breast cancer, we will outline clinical trial data on the use of FGFR-targeted therapies in cancer …
[HTML][HTML] Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance
MA Krook, JW Reeser, G Ernst, H Barker… - … Journal of Cancer, 2021 - nature.com
… Fibroblast growth factor receptors (FGFRs) are aberrantly activated … fibroblast growth factor
receptor (FGFR) family of receptor tyrosine kinases consists of four transmembrane receptors…
receptor (FGFR) family of receptor tyrosine kinases consists of four transmembrane receptors…
[HTML][HTML] Fibroblast growth factor receptor fusions in cancer: opportunities and challenges
L Chen, Y Zhang, L Yin, B Cai, P Huang, X Li… - … & Clinical Cancer …, 2021 - Springer
… Fibroblast growth factors (FGFs) and their receptors (FGFRs) play critical roles in many
biological processes and developmental functions. Chromosomal translocation of FGFRs result …
biological processes and developmental functions. Chromosomal translocation of FGFRs result …
The role of fibroblast growth factor receptor (FGFR) protein-tyrosine kinase inhibitors in the treatment of cancers including those of the urinary bladder
R Roskoski Jr - Pharmacological Research, 2020 - Elsevier
… the growth factors, … fibroblast growth factor receptors (FGFRs). FGF11/12/13/14 do not
interact with the transmembrane FGFRs; of the 22 FGFs, a total of 18 of these function as receptor …
interact with the transmembrane FGFRs; of the 22 FGFs, a total of 18 of these function as receptor …
[HTML][HTML] Targeting cancer associated fibroblasts in liver fibrosis and liver cancer using nanocarriers
L Kaps, D Schuppan - Cells, 2020 - mdpi.com
… functional cell surface proteins like platelet-derived growth factor receptor β (PDGFRβ) or the
insulin-like growth factor receptor II (IGFRII). Notably, if … bFGF basic fibroblast growth factor …
insulin-like growth factor receptor II (IGFRII). Notably, if … bFGF basic fibroblast growth factor …
Fibroblast growth factor receptor (FGFR) inhibitors: A review of a novel therapeutic class
A Weaver, JB Bossaer - Journal of Oncology Pharmacy …, 2021 - journals.sagepub.com
… Fibroblast growth factor receptors (FGFRs) are expressed on cell membranes and comprise
a family … These receptors are ligand-dependent with fibroblast growth factors (FGFs) binding …
a family … These receptors are ligand-dependent with fibroblast growth factors (FGFs) binding …
[HTML][HTML] Dual vascular endothelial growth factor receptor and fibroblast growth factor receptor inhibition elicits antitumor immunity and enhances programmed cell …
H Deng, A Kan, N Lyu, L Mu, Y Han, L Liu, Y Zhang… - Liver cancer, 2020 - karger.com
… many different vascular-targeted TKIs, and each has their own targeting profile. For example,
lenvatinib targets fibroblast growth factor receptor 1 (FGFR1) and cabozantinib targets the c-…
lenvatinib targets fibroblast growth factor receptor 1 (FGFR1) and cabozantinib targets the c-…
Discovery of roblitinib (FGF401) as a reversible-covalent inhibitor of the kinase activity of fibroblast growth factor receptor 4
RA Fairhurst, T Knoepfel, N Buschmann… - Journal of medicinal …, 2020 - ACS Publications
… Fibroblast growth factor receptor 4 (FGFR4) belongs to the FGFR family of four receptor
tyrosine kinases that interact with fibroblast growth factors (FGFs) to regulate key developmental …
tyrosine kinases that interact with fibroblast growth factors (FGFs) to regulate key developmental …
[HTML][HTML] INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor …
PCC Liu, H Koblish, L Wu, K Bowman, S Diamond… - PLoS …, 2020 - journals.plos.org
… Alterations in fibroblast growth factor receptor (FGFR) genes have been identified as …
Pharmacological targeting of FGFRs may therefore provide therapeutic benefit to selected cancer …
Pharmacological targeting of FGFRs may therefore provide therapeutic benefit to selected cancer …
Fibroblast growth factor‐2, derived from cancer‐associated fibroblasts, stimulates growth and progression of human breast cancer cells via FGFR1 signaling
… Analysis of data from The Cancer Genome Atlas revealed that fibroblast growth factor-2 (FGF2) …
; FGFR, fibroblast growth factor receptor; NFs, normal fibroblasts [Color figure can be …
; FGFR, fibroblast growth factor receptor; NFs, normal fibroblasts [Color figure can be …