… their ability to uncouple immunoregulatory pathways at play … been initiated to investigate the
effectiveness of using a CD40 … , thereby minimizing off-target toxicities, have been proposed. …

… might cause subsequent systemic toxicities. In a safer … the disruption efficiency minimized
with increased numbers of target … In a case study, PD-1 blockade increased CAR T cell efficacy …

… by inhibiting STAT3 signaling in renal cell carcinoma [89]. … BRAF and MEK signaling together
could increase the efficacy of … this toxicity while sparing the anti-tumorigenic effects of PD-1 …

… the ETC, and an uncoupling effect was primary evident when … SMIP004-7 (100 mg/kg, ip)
combined with anti-PD-1 (5 mg/kg… glycemia by blocking glucose re-uptake in the kidney. Recent …

… the treatment of melanoma, lung, kidney, bladder, head, and … made to uncouple its toxicity
and efficacy and potentiate its … PD-1 inhibits T cell activation by targeting the signaling of the …

… -small cell lung cancer (NSCLC) and renal cell carcinoma (RCC), … This is due to inadequate
priming prior to PD-1 blockade … to uncouple the cell to TCR signal transduction pathways by …

… be highest in the heart and kidney, indicating the importance of protein … The uncoupling of
eNOS in the vascular system leads to a … The PD-1/PD-L1 pathway suppresses the response of …

… release while retaining T cell engaging therapy efficacy. … Importantly, it was associated with
few toxic effects. The … , liver, and renal cell carcinomas. It was reported that the upregulation of …

… can inhibit the PD-1/PD-L1 pathway and suppress tumor … likely to have rejection than kidney
transplantation; the incidence … superior therapeutic effect and less toxicity [84]. Before using …

… the antibodies targeting inhibitory checkpoints on T cells, such as PD-1 (… of Akt signaling,
thereby uncoupling Akt signaling from … will likely pave the way for the development of less toxic, …