… epithelium and NE cells within kidney and stomach Phase 1a … with knockdown or knockout
of the PD-1 gene in CAR T cells… and T cell activation are uncoupled, effectively rendering the …

… transporter 1 (Glut1) in renal cell carcinoma with T cell function … These studies mostly focus
on the inhibition of the PD-1/PD-… uncouple antigen recognition from CAR activation signaling. …

… Although targeting mTOR signaling may be expected to exhibit potent antitumor im…
Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal …

… In tumor immunity, melanoma biospecimens after PD-1 … and are hyper-responsive to
renal cell carcinoma (RCC)-… significant dose-limiting on-target toxicity, which may be due to …

… has been used in the treatment of kidney cancers, as well as … preventing the accumulation
of toxic metabolites, causing an … by the PD-1 checkpoint receptor, and mTOR signaling has …

… was due to butyrate uncoupling the TCA from glycolysis, … and kidney tissues, overall leading
to T cell-mediated ureteritis, and … the efficacy of the association of SCFAs and PD-1 ICB in …

… several signaling pathways would participate in the PD-1/PD-… or poor-risk advanced renal
cell carcinoma (RCC), MSI-H/… Although the clinical effectiveness of these ICIs gained great …

… PD-1 plays an important role in the T cell exhaustion [85]. … by the US FDA for advanced renal
cell carcinoma, hepatocellular … Evidence suggested that SPRY proteins uncoupled multiple …

… These retrospective series of kidney transplant recipients … (PD-L1) inhibitors that uncouple
two key mechanisms of T-cell … not systemic, immunotherapy with anti-PD-1/toll like receptor 9 …

… We present the case of an allogenic kidney transplant patient who developed regionally …
Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal …