Bile acid signaling in neurodegenerative and neurological disorders

SM Grant, S DeMorrow - International Journal of Molecular Sciences, 2020 - mdpi.com
… Some bile acids, such as tauroursodeoxycholic acid and … linked to ER stress, unfolded protein
response (UPR) activation … with a reduced bile acid pool [19], or inhibiting ASBT activity in …

Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response

Y Hou, J Luan, T Huang, T Deng, X Li, Z Xiao… - Journal of …, 2021 - Springer
… abolishes unfolded protein response (UPR) activation to ameliorate axonal degeneration
in … glial scar generates a dense barrier which inhibits axon regeneration at the lesion site [44]. …

Trazodone, dibenzoylmethane and tauroursodeoxycholic acid do not prevent motor dysfunction and neurodegeneration in Marinesco-Sjögren syndrome mice

G Lavigna, A Grasso, C Pasini, V Grande, L Mignogna… - bioRxiv, 2024 - biorxiv.org
… We also tested the chemical chaperone tauroursodeoxycholic acid (TUDCA), which can …
Tauroursodeoxycholic bile acid arrests axonal degeneration by inhibiting the unfolded protein

Linking nonalcoholic fatty liver disease and brain disease: focusing on bile acid signaling

ZL Ren, CX Li, CY Ma, D Chen, JH Chen… - International Journal of …, 2022 - mdpi.com
… brain are regulated by the bile acid-activated receptors FXR … From a bile acid viewpoint, we
examine the bile acid signaling … Inhibiting bile acid synthesis in the liver, controlling bile acid

Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation

P Bhargava, MD Smith, L Mische… - The Journal of …, 2020 - Am Soc Clin Investig
… of bile acids in MS, we studied the in vitro effects of an endogenous bile acid,
tauroursodeoxycholic acid … effects of bile acid ligands in immune cells including inhibition of the …

Endoplasmic reticulum stress and unfolded protein response in neurodegenerative diseases

R Ghemrawi, M Khair - International journal of molecular sciences, 2020 - mdpi.com
… (4-PBA) and tauroursodeoxycholic acid (TUDCA) have shown … binds to unfolded or misfolded
proteins, inhibits protein … GSK2606414 delayed Purkinje cell degeneration, prolonged the …

Tauroursodeoxycholic acid alleviates pulmonary endoplasmic reticulum stress and epithelial-mesenchymal transition in bleomycin-induced lung fibrosis

B Tong, L Fu, B Hu, ZC Zhang, ZX Tan, SR Li… - BMC Pulmonary …, 2021 - Springer
… was inhibited by … unfolded protein response (UPR) are involved in BLM-induced pulmonary
EMT and lung fibrosis [11, 12]. Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, …

[HTML][HTML] Endoplasmic reticulum stress-associated neuronal death and innate immune response in neurological diseases

M Shi, Y Chai, J Zhang, X Chen - Frontiers in immunology, 2022 - frontiersin.org
… export of misfolded/unfolded proteins from the ER to the … Inhibiting ER stress by
Tauroursodeoxycholic acid (TUDCA) … loss, demyelination, or axonal degeneration in the CNS of …

Activating cannabinoid receptor 2 preserves axonal health through GSK-3β/NRF2 axis in adrenoleukodystrophy

J Parameswaran, L Goicoechea, L Planas-Serra… - Acta …, 2022 - Springer
… of CB2r (JWH133) halted axonal degeneration and associated … The drug effectively inhibited
axonal damage through the … targets, not only to arrest overt inflammatory demyelination of …

Can endoplasmic reticulum stress observed in the PTZ-kindling model seizures be prevented with TUDCA and 4-PBA?

Z Doğanyiğit, A Okan, E Akyüz, S Yılmaz, Ş Ateş… - European Journal of …, 2023 - Elsevier
… of Tauroursodeoxycholic acid (TUDCA) and 4-phenyl-butyric … of misfolded and unfolded
proteins causes the separation of … Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, …