The differential in vivo contribution of spinal α2A- and α2C-adrenoceptors in tonic and acute evoked nociception in the rat

G López-Córdoba, G Martínez-Lorenzana… - Frontiers in …, 2022 - frontiersin.org
… on spinal analgesia supports the relevance of α 2A and … is mediated by α 2A - but not α
2B/2C -adrenoceptor activation. … type of adrenergic receptor stimulated, the localization of the …

… μ-opioid receptor in the rat spinal cord contributes to the α2-adrenoceptor agonist dexmedetomidine-induced attenuation of chronic morphine tolerance in cancer pain

P Zhang, J Bu, X Wu, L Deng, M Chi, C Ma… - Journal of Pain …, 2020 - Taylor & Francis
… Opioid receptor internalization and desensitization mediated … Opioid and adrenergic receptors
both belong to the family of … DEX relieved the cancer-evoked pain in the state of morphine …

Dexmedetomidine modulates transient receptor potential vanilloid subtype 1

BM Lee, Y Jang, G Park, K Kim, SH Oh, TJ Shin… - Biochemical and …, 2020 - Elsevier
… 2 adrenergic receptor agonist and novel sedative drug with minimal respiratory suppression,
have shown anti-nociceptive activity in various pain … -mediated analgesic effect [12]. It would …

Dexmedetomidine Inhibits ASIC Activity via Activation of α2A Adrenergic Receptors in Rat Dorsal Root Ganglion Neurons

S Wei, CY Qiu, Y Jin, TT Liu, WP Hu - Frontiers in Pharmacology, 2021 - frontiersin.org
… DEX suppressed ASIC-mediated and acid-evoked currents and … α2-ARs mediate DEX-induced
inhibition of ASIC currents in … of ASIC-mediated the electrophysiological activity and pain, …

Alpha2-adrenergic receptors

E Listik, Q Wang - Primer on the Autonomic Nervous System, 2023 - Elsevier
… , are primarily mediated by the α 2A - subtype. Conversely, the … agonist-mediated lowering
of blood pressure can occur in mice heterozygous for the α 2A -AR, whereas agonist-evoked

Activation of the α2B adrenoceptor by the sedative sympatholytic dexmedetomidine

D Yuan, Z Liu, J Kaindl, S Maeda, J Zhao, X Sun… - Nature chemical …, 2020 - nature.com
… The adrenergic receptors (ARs), which mediate … the analgesic effects of nitrous oxide 11
, and is responsible for vasoconstriction in some vascular beds 13 . The α 2C AR and α 2A AR …

Effects of administration of α2 adrenergic receptor agonist into psoas major muscle on inflammatory pain induced by injection of complete Freund's adjuvant in rats

X Guo, Y Xue, W Ji, J Liang, Z Qingshi - Molecular Pain, 2022 - journals.sagepub.com
analgesia of α 2 receptor agonists report that local analgesia is mediated by α 2 adrenergic
receptors … and density of α 2 adrenergic receptor subtypes in different peripheral organs and …

Suppression of P2X3 receptormediated currents by the activation of α2Aadrenergic receptors in rat dorsal root ganglion neurons

JW Hao, WL Qiao, Q Li, S Wei, TT Liu… - CNS Neuroscience …, 2022 - Wiley Online Library
… ,β-meATP-evoked currents by DEX was blocked by the α 2A -AR … (α 2 -ARs) play a key role
in mediating pain modulatory … Among all subtypes, P2X3 receptor subtype is mainly located in …

Long-term application of adrenergic agonists modulates nociceptive ion channels

AS Medrado, NAS Santiago, ER Moraes… - Neuroscience …, 2024 - Elsevier
… Selective agonists for α2, β1 and β3-adrenergic receptors … Currents evoked by agonists
were measured under voltage … suggested an effect mediated by the α1-receptor [22]. The α1-…

Baicalin relieves neuropathic pain by regulating α2adrenoceptor levels in rats following spinal nerve injury

LJ Huang, SS Jia, XH Sun, XY Li… - Experimental and …, 2020 - spandidos-publications.com
… included nonselective α2‑AR antagonist idazoxan, α2a‑AR … model of carrageenan-evoked
thermal hyperalgesia in rats … of spinal 5-HT3 receptors reduced α2-adrenoceptor-mediated