… different subtypes of adrenergic receptors (AR). Dexmedetomidine evokes a short hypertensive
phase mediated … Dexmedetomidine binds to α2A-AR subtype of α2-AR causing transient …

… addictive.α 2 adrenergic receptor agonists are often used in … The α 2a subtype is contained
in the spinal dorsal horn and … elicit peripheral- and central-mediated analgesic actions [15]. …

… adrenergic receptors (ARs). ARs have three sub-classes each with three receptor subtypes:
α1- (α 1A , α 1B, α 1D ), α2- (α 2A … NA evokes hyperpolarization of LC noradrenergic neurons …

… Cognitive reserve is a concept evoked to explain the … of α2-adrenergic receptors in the human
brain are of the α2A … anesthetics are mediated by α2 receptors on non-adrenergic neurons …

… The receptors that mediate the effects of norepinephrine and … of α2-adrenergic agonists
resulted in a decrease in pain, … proteins, such as the α2A adrenergic receptor in complex with an …

… topically applied α2- adrenergic receptor agonists may have … the PAG mediating a “top-
down” endogenous pain inhibition … commonly report spontaneous pain (ie, non- evoked pain) as …

… predominately mediates excitatory effects through its receptor… configuration includes
combinations of α2 through α6 and β2 … by the α4β2 nAChR agonist-evoked ACh increases in the …

… into the cell in order to mediate the corresponding functional … G protein-coupled receptor,
The α2 adrenergic receptor (AR) … (84,85), evoke sedation (85), reduce pain perception (85,86), …

… of spinal analgesic synergy between Gα i/o GPCR agonists … the GluN2A subunit, also mediate
the LS that is unmasked by … GPCRs is therefore sufficient to evoke a cAMP overshoot and …

… ), opioids, α2 adrenergic receptors (α2-AR) agonists, and plant-… -AR agonist phenylephrine
evoked prolonged pain and more … effect, which may be partially mediated by α2-AR and PGE …