… , an inflammatory disorder of the vascular system. Recent … inflammation represent an
important area of research, as they are major challenges, both for our society and our health system…

… Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle
cells, and macrophages: Implications for CD40-CD40 ligand signaling in atherosclerosis. …

… IL-6 is another inflammatory cytokine involved in the inflammatory cascade. … atherothrombosis
resulting from modulation of endothelial dysfunction, NET formation and inflammatory …

… Inflammation regulates atherogenesis and soluble CD40 ligand (sCD40L) is an inflammatory
mediator associated with the presence of single-territorial atherosclerosis. We assessed …

… for deficiency of platelet CD40L in an atherothrombosis model, confirming the importance of
… IFN-γ pathway while platelet CD40L regulates atherothrombosis. Taken together, these data …

… The CD40–CD40 ligand (CD40L) dyad represents a scientific and clinical field that has …
Lower panel: Key mechanisms of inflammation, atherothrombosis, oxidative stress and …

… genes linked to immune pathways and inflammatory responses, such as cytokine and
chemokine signalling, while upregulated genes were involved in pathways linked to extracellular …

… Inflammation contributes to the initiation and progression of atherosclerosis, although the
underlying inflammatory … Specifically, the role of the proinflammatory soluble CD40 ligand (…

… Taking together, these data suggest that sCD40L may act as a mediator at the interface of
metabolic and atherothrombotic disease, thus modulating different aspects of inflammation-…

… Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle
cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis. …