Role of CD40 (L)-TRAF signaling in inflammation and resolution—a double-edged sword
… , an inflammatory disorder of the vascular system. Recent … inflammation represent an
important area of research, as they are major challenges, both for our society and our health system…
important area of research, as they are major challenges, both for our society and our health system…
Deficiency of endothelial CD40 induces a stable plaque phenotype and limits inflammatory cell recruitment to atherosclerotic lesions in mice
MC Gissler, P Scherrer, N Anto-Michel… - Thrombosis and …, 2021 - thieme-connect.com
… Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle
cells, and macrophages: Implications for CD40-CD40 ligand signaling in atherosclerosis. …
cells, and macrophages: Implications for CD40-CD40 ligand signaling in atherosclerosis. …
A link between inflammation and thrombosis in atherosclerotic cardiovascular diseases: Clinical and therapeutic implications
E Oikonomou, M Leopoulou, P Theofilis… - Atherosclerosis, 2020 - Elsevier
… IL-6 is another inflammatory cytokine involved in the inflammatory cascade. … atherothrombosis
resulting from modulation of endothelial dysfunction, NET formation and inflammatory …
resulting from modulation of endothelial dysfunction, NET formation and inflammatory …
The proinflammatory soluble CD40 ligand is associated with the systemic extent of stable atherosclerosis
T Pereira-da-Silva, P Napoleão, T Pinheiro, M Selas… - Medicina, 2021 - mdpi.com
… Inflammation regulates atherogenesis and soluble CD40 ligand (sCD40L) is an inflammatory
mediator associated with the presence of single-territorial atherosclerosis. We assessed …
mediator associated with the presence of single-territorial atherosclerosis. We assessed …
Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease
… for deficiency of platelet CD40L in an atherothrombosis model, confirming the importance of
… IFN-γ pathway while platelet CD40L regulates atherothrombosis. Taken together, these data …
… IFN-γ pathway while platelet CD40L regulates atherothrombosis. Taken together, these data …
CD40/CD40L and related signaling pathways in cardiovascular health and disease—the pros and cons for cardioprotection
… The CD40–CD40 ligand (CD40L) dyad represents a scientific and clinical field that has …
Lower panel: Key mechanisms of inflammation, atherothrombosis, oxidative stress and …
Lower panel: Key mechanisms of inflammation, atherothrombosis, oxidative stress and …
Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state
LA Bosmans, CM van Tiel, SABM Aarts… - Cardiovascular …, 2023 - academic.oup.com
… genes linked to immune pathways and inflammatory responses, such as cytokine and
chemokine signalling, while upregulated genes were involved in pathways linked to extracellular …
chemokine signalling, while upregulated genes were involved in pathways linked to extracellular …
[HTML][HTML] Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
T Pereira-da-Silva, P Napoleao, T Pinheiro… - American Journal of …, 2020 - ncbi.nlm.nih.gov
… Inflammation contributes to the initiation and progression of atherosclerosis, although the
underlying inflammatory … Specifically, the role of the proinflammatory soluble CD40 ligand (…
underlying inflammatory … Specifically, the role of the proinflammatory soluble CD40 ligand (…
Role of the CD40-CD40 Ligand Pathway in Cardiovascular Events, Neurological Alterations, and Other Clinical Complications of Chronic Hemodialysis Patients …
… Taking together, these data suggest that sCD40L may act as a mediator at the interface of
metabolic and atherothrombotic disease, thus modulating different aspects of inflammation-…
metabolic and atherothrombotic disease, thus modulating different aspects of inflammation-…
The CD40-CD40L dyad as immunotherapeutic target in cardiovascular disease
… Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle
cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis. …
cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis. …