… cleaved by either ADAM10 or lysosomal proteases, and the remaining membrane associated
LOX1 NTFs are cleaved by SPPL2a… -induced proliferation in B and T cells (39, 159). Even …

… by ADAM10 and cleavage in lysosomes generate membrane-bound LOX-1 NTFs, which are
then further processed by SPPL2a/b [39]. … If and to what extent activation of T cells and T cell-…

… on how selective SPPL2-mediated cleavage is or whether … ADAM10/17 but also lysosomal
proteases. In a second mode, … molecular weight of the released intracellular domains (ICDs) …

… could confirm cleavage of endogenous VAMP1-4 by SPPL2a/… antigen receptor (CAR) T cells
and impairment of anti-tumour … Fas ligand intracellular domain is released by ADAM10 and …

… extracellular domain of the Notch receptor at the s2 cleavage … For T-cells, the strength of
Notch signaling has been … T cell migration (42, 43), FAS ligand (FASL), which in a soluble form …

… primary T cells … ADAM10 cleavage was found to be coupled to intracellular shedding,
mediated by the signal peptide peptidase-like 2a (SPPL2A), which generates a free intracellular …

… Expressed by activated B and T-cells, m-CD95L contributes to the … ADAM10-mediated
cleavage, with the SPPL2a-mediated cleavage of the CD95L intracellular region to release …

… Although CD95L expression at the surface of activated T-cells … -10 (ADAM-10)-dependent
mechanism releasing sCD95L … (SPPL2a) engendering the release of the intracellular region of …

… In addition, biotinylated recombinant hFasL bound to EL4 mouse T cells expressing hDR5.
… -inducing ligand (TRAIL). Biotinylated hTRAIL bound to EL4 mouse T cells expressing hDR5 …

… proteases cleavage sites are only known for either the secreted peptide or the … The Fas
ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells…