HPV16 E6 enhances the radiosensitivity in HPV-positive human head and neck squamous cell carcinoma by regulating the miR-27a-3p/SMG1 axis

D Long, L Xu, Z Deng, D Guo, Y Zhang, Z Liu… - … Agents and Cancer, 2021 - Springer
… , E6 promotes cell proliferation, apoptosis resistance and … apoptosis of cervical cancer, gastric
cancer and colon cancer cells [… mechanism of HPV16 E6 in HNSCC radiation therapy and …

[HTML][HTML] HPV transcript expression affects cervical cancer response to chemoradiation

FJ Ruiz, M Inkman, R Rashmi, N Muhammad… - JCI insight, 2021 - ncbi.nlm.nih.gov
… correlates with resistance to radiation in cervical cancer cells, … HPV 16 E6 and E6* protein
coding sequences were ligated into … and E6* from HPV 16, we demonstrate that transcript …

Nimotuzumab combined with irradiation enhances the inhibition to the HPV16 E6-promoted growth of cervical squamous cell carcinoma

Z Xu, H Shu, F Zhang, W Luo, Y Li, J Chu… - Frontiers in …, 2020 - frontiersin.org
… and radiation remarkably reduced the protein expression … ; HPV16 causes about 55% of
cervical cancer cases; HPV16resistance caused by radiation (39). Importantly, nimotuzumab …

Role of the JAK/STAT pathway in cervical cancer: its relationship with HPV E6/E7 oncoproteins

A Gutiérrez-Hoya, I Soto-Cruz - Cells, 2020 - mdpi.com
… in the HPV16+ and HPV18+ cervical cancer cell lines … of SOCS1 in cervical tumor cells
confers radioresistance [160]. … , which reduce the resistance of cervical tumor cells to cisplatin …

Do or die: HPV E5, E6 and E7 in cell death evasion

J Skelin, I Sabol, V Tomaić - Pathogens, 2022 - mdpi.com
… for cisplatin therapy resistance in cases of cervical cancer and mutations … target of E7 is the
tumor suppressor retinoblastoma protein (… HPV 16 oncoproteins expressed in primary human …

[HTML][HTML] Human papillomavirus E6/E7 oncoproteins promote radiotherapy-mediated tumor suppression by globally hijacking host DNA damage repair

D Bruyere, P Roncarati, A Lebeau, T Lerho… - Theranostics, 2023 - ncbi.nlm.nih.gov
cancer cells transduced with HPV16 E6 and/or E7 or firefly luciferase (control) were exposed
to 0, 2 or 4 Gy irradiation… DNA damage/repair proteins targeted by HPV16 E6 and/or E7 are …

Is viral E6 oncoprotein a viable target? A critical analysis in the context of cervical cancer

A Kumar, E Rathi, RC Hariharapura… - Medicinal research …, 2020 - Wiley Online Library
… target HPV16 E6 protein. In comparison to previously reported synthetic peptides, one of
the antibodies (GTE6-1) had a high affinity of 60 nM for HPV16 E6 protein and suppressed E6-…

Human papillomaviruses as infectious agents in gynecological cancers. Oncogenic properties of viral proteins

DA Haręża, JR Wilczyński, E Paradowska - International journal of …, 2022 - mdpi.com
… role of STAT1 in cervical cancer, especially in cervical lesions. … samples compared to resistant
cases suggest that STAT1 may … with HPV16 E6 and E7 expression in keratinocytes and in …

Biology of the radio-and chemo-responsiveness in HPV malignancies

MT Spiotto, CM Taniguchi, AH Klopp, LE Colbert… - Seminars in radiation …, 2021 - Elsevier
HPV16 E6 in the HPV-negative C33 cervical cancer cell line increased resistance to
radiation… The HPV oncoprotein E6 oncoprotein can bind to XRCC1, a protein required for single …

[HTML][HTML] Molecular pathways in the development of HPV-induced cervical cancer

FR Bonab, A Baghbanzadeh, M Ghaseminia… - EXCLI …, 2021 - ncbi.nlm.nih.gov
… and the development of human cervical cancer. E6 and E7 proteins of HPV have a
pivotal role … Previous studies show the ability of HPV 16 E6 to cooperate with E6AP in Wnt/β-catenin …