This study aimed to investigate: 1) the influence of 4C learning model on students' learning outcomes in the philosophy of science course, 2) the influence of academic capability on students' learning outcomes in the philosophy of science course, and 3) the interaction between 4C learning model and academic capability on the students' learning outcomes in the philosophy of science course, in cognitive, psychomotor, and affective domains at UIN Walisongo Semarang academic year of 2019/2020. This study was a quasi-experimental research with 2x3 factorial design. The study was conducted at UIN Walisongo Semarang academic year of 2019/2020 on the first years students of Islamic Communication Department. Techniques in collecting the data were multiple choice tests, essay tests, observations, and documentation. The hypothesis testing used two-way ANOVA test with a significance level of 5%. The result of it related to the influence of 4C model on the students' learning outcomes had showed