… We also describe the basic signaling properties of MAPKs (… In addition, for accurate signal
transmission both MAPK … the signaling properties of MAPKs in response to different stimuli, …

… five layers of protein kinases known as MAPK kinase kinase kinase (MAP4K), … signalling
networks, the MAPK signal transmission pathway plays an important role in controlling various …

… establishment of MAPK cascades as essential components in … Yet, they carry out a diverse
array of biological functions in … negative regulation in the signaling pathways, respectively. …

… of the mitogen-activated protein kinase (MAPK) family, which are found in all … Signal
transduction by p38 kinases … and key targets implicated in various cellular processes (Fig. 3). …

… The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various cellular
… EGFRs regulate the proliferation of tumor cells through signal transduction pathways. …

… revealed that the MAPK cascade also plays crucial roles in … signal transduction processes
through MAPK cascades. A typical MAPK cascade is composed of MAPK (MPK), MAPK kinase …

… represent ubiquitous signal transduction pathways that regulate all aspects of life and are …
results support a key role for the JNK pathway in mediating resistance to various targeted and …

… the diverse modulators regulating the MAPK/ERK signaling … defined various molecular
signaling pathways that are critical to … ), Wnt/β-catenin, Janus kinase/signal transducer activator of …

… transduction is a fundamental process in the development and progression of cancer.
Modifications in various cell signalling pathways … such as the mitogen-activated protein kinases (…

… phosphorylation at the end of a cascade composed of a MAPK kinase (MKK) and an MKK
… Several studies have shown that p38 kinases play an important role in different aspects of …