[HTML][HTML] An Insight on Protein Kinases and Their Therapeutic Perspective

AK Dhal, P Ritaparna - 2024 - intechopen.com
… a crucial role in two-component signal transduction pathways. … the histidine kinases involved
in different signal transduction … makes up the MAP kinase signal transduction pathway [24]. …

Interleukin-6: a masterplayer in the cytokine network

P Uciechowski, W Dempke - Oncology, 2020 - karger.com
… There are various signaling pathways for IL-6, and many of the … and PI3 kinase pathways,
and the signal transducer and … is important for the initiation of the PI3K/AKT and the MAPK

Understanding the integrated pathways and mechanisms of transporters, protein kinases, and transcription factors in plants under salt stress

WH Shah, A Rasool, S Saleem… - … Journal of Genomics, 2021 - Wiley Online Library
… in integrating different stress-signalling pathways which are … phosphorylation targets including
signal transduction proteins [80… Different signalling components together play an important

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
… of various proinflammatory genes and also serve as the critical … non-canonical NF-κB pathway
occurs through a handful of … , and protein kinases are involved in the various pathways to …

Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
… This review focuses on the important signaling pathways, … STING-mediated cytokines
also showed diverse … (ERK1/2) and p38-mitogen-activated protein kinase (MAPK) might be …

Targeting aberrant RAS/RAF/MEK/ERK signaling for cancer therapy

U Degirmenci, M Wang, J Hu - Cells, 2020 - mdpi.com
… further solidified its role at the plasma membrane as a signal transducer [10,11]. In the effort
to … As an important signaling process, the GTP/GDP cycle is regulated by various stimuli, …

Endothelial tight junctions and their regulatory signaling pathways in vascular homeostasis and disease

X Cong, W Kong - Cellular signalling, 2020 - Elsevier
… the paracellular pathway, serving as an important barrier in … of endothelial TJs in diverse
vascular systems and ECs. More … , and apoptosis) due to their signal transduction abilities [4,5]. …

Targeting integrin pathways: mechanisms and advances in therapy

X Pang, X He, Z Qiu, H Zhang, R Xie, Z Liu… - Signal Transduction …, 2023 - nature.com
… and transducers in biochemical and mechanical signals between … -mediated downstream
signal transduction to highlight … , and the key points for clinical research, basic research, and …

Regulation of the expression of heme oxygenase-1: Signal transduction, gene promoter activation, and beyond

MV Medina, D Sapochnik, M Garcia Solá… - … & Redox Signaling, 2020 - liebertpub.com
… triggered by oncogenes in which HO-1 plays a critical role is of … mitogen-activated protein
kinases (MAPKs) are the best … can provide phosphorylation sites for various kinases. Protein …

[HTML][HTML] The JAK-STAT pathway at 30: Much learned, much more to do

RL Philips, Y Wang, HJ Cheon, Y Kanno, M Gadina… - Cell, 2022 - cell.com
… of the Janus kinase (JAK)-signal transducer and activator of … the proteins required for both
type I and type II IFN signaling, … (uSTAT non-canonical pathways). Multiple inducible negative …