… Moreover, Stil knockdown has an effect on Chfr, a protein that blocks mitosis when cells
are stressed by reducing activated CDK1/Cyclin B (Castiel et al., 2011). In addition, …

… regulating centrosome integrity and mitotic spindle organization [41]. We and others previously
showed that excess STIL … Our results showed that STIL knockdown not only suppressed …

… PAR, which is synthesized by PARP2 but not PARP1 at mitotic centrosomes, … suppress
PARP2-synthesized PAR and induce cell senescence by abrogating the correction of mitotic …

… genome integrity and the expression of dedicated proteins to … regulate the coupling between
DNA replication and mitosis. … lesions for mediators such as CHFR ubiquitin E3 ligases [108…

… is normally suppressed in cells with intact centrioles, depletion of certain suppressor proteins
… death of cells with an excessive number of centrosomes through abnormal mitosis. Studies …

DNA double-strand breaks (DSBs) are the most lethal DNA damages which lead to severe
genome instability. Phosphorylation is one of the most important protein post-translation …

… in the presence of compounds targeting genome integrity, cell cycle progression, transcription,
… Not only does removal of FBXO42 in HAP1 and U2OS cells cause sensitivity to various …

… all together on the de-repression of the E2F transcription factor, … of proteins including DNA
damage sensors, transducers, mediators and effectors, which overall safeguards the integrity …

… Here, we report a novel role of the 14-3-3-protein family29 in regulating centrosome number.
… The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr. J. …

… point, become committed to mitosis and prioritize completion of cell division over repair of
DNA … signaling in mitosis. First, little or no transcription occurs during mitosis except possibly at …