… Bruton’s tyrosine kinase (BTK), specific inhibitors of the other TEC … T-cell kinase (ITK or
TSK/EMT), tyrosine kinase expressed in … All Tec family kinases also contain two SRC homology …

… tyrosine kinase (BTK), a cytoplasmic protein tyrosine kinase, … Tec homology (TH) region,
which is unique for the Tec family. … to the other Tec family PTKs ITK, TEC, BMX and TXK (36, 37)…

… Frk)42 and the five TFK members (Tec, Itk, Btk, Bmx and Txk)43 display cell type- specific …
Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs …

… distantly related kinases, though they have had variable success at limiting cross-reactivity
within the more closely related TEC family of kinases. We investigated the BTK specificity and …

… isoforms of BTK in humans and other mammals (Figure 1). … original isoform of BTK in B
cells (which we refer to BTK-A for … homology (PH) domain followed by a Tec homology (TH) …

… ITK (OnITK) were remarkably conserved with its homologues … Bruton's tyrosine kinase (BTK),
bone marrow tyrosine kinase … (BMX), resting lymphocyte kinase (RLK) and tyrosine kinase …

… , restriction factors, and nonreceptor tyrosine kinases, which are the … The Tec family kinases
Itk and Btk promote antigen receptor … homology (PH) and Tec homology (TH) domains. When …

… , belongs to the Tec family of non-receptor tyrosine kinases (BTK, ITK, TEC, BMX, and
TXK), which is one of the largest kinase families in mammals1, 2. …

… The Tec kinase family, which includes BTK, TEC, ITK, BMX, and RLK, is the second largest
family of cytoplasmic tyrosine kinases [12]… homology domain) and continuing through the TEC …

… BTK is a 77kDa cytoplasmic, nonreceptor tyrosine kinase … homology, Tec homology,
Src-homology 3, Src-homology 2, … BTK over some SRC kinases (BLK), TEC kinases (BMX, ITK, …