… Furthermore, we assessed cardiac maturity by measuring the … We also measured medium
pyruvate, since the ratio between lactate and pyruvate (L:P) reflects the intracellular redox state…

… rearrange eqn (4) to estimate the cytosolic redox state: … Moreover, in both skeletal and cardiac
muscle, oxamate, a well-… rather lactate must first be converted to pyruvate in the cytosol or …

… occurring in the cytoplasm, converts glucose and nicotinamide adenine … will increase lactate
production yet preserve the lactate–pyruvate ratio. … NAD Nicotinamide adenine dinucleotide …

… Reduced nicotinamide adenine dinucleotide … lattice without sarcolemma and cytosol.
Trabeculae were exposed acutely to … pyruvate shuttling and instead reduction of pyruvate to …

… lactate-to-pyruvate ratio is frequently used as a proxy for the cytosolic NADH-to-NAD + ratio.
Nicotinamide adenine dinucleotide … oxidative reactions in the cytosol and mitochondria. As a …

… be reserved to mitochondrial nicotinamide adenine dinucleotide hydride (NADH) and …
pyruvate and NADH in the cytoplasm. In the absence of oxygen, pyruvate is reduced to lactate (or …

… Lactate and pyruvate together serve as a circulating redox … may buffer their NAD and NADH
pools with the cytosol 45 . … and heart showed a decreased NADH-to-NAD ratio 46 . Thus, …

… the cellular redox state, and exogenous pyruvate can influence … In the cytoplasm, PYR can
be reduced to lactate (LA) via LA … reduced form of nicotinamide adenine dinucleotide (NADH) …

… to lactate and pyruvate concentrations of perfused rat hearts … by nicotinamide adenine
dinucleotide phosphate (NADP + )-dependent malic enzyme 46 generating malate in the cytosol. …

… )-mediated conversion of pyruvate to lactate in the cytosol, as … information about the
cellular redox state in the region of … glucose, lactate, and pyruvate levels were measured from …