Targeting cardiac metabolic pathways: a role in ischemic management

AS Yehualashet, TF Belachew, ZD Kifle… - Vascular Health and …, 2020 - Taylor & Francis
… Reducing equivalents nicotinamide adenine dinucleotide (… Firstly, FAs should move from
the plasma to the cytoplasm and … oxidation by the heart and enhance the oxidation of pyruvate

[HTML][HTML] Metabolic therapy of heart failure: Is there a future for B vitamins?

J Piquereau, SE Boitard, R Ventura-Clapier… - International Journal of …, 2021 - mdpi.com
cytosol by metabolizing glucose to pyruvate, which generates 2 ATP molecules. Pyruvate is
then either converted to lactate … and oxidized nicotinamide-adenine dinucleotide. Biochem. J. …

Myocardial blood flow control by oxygen sensing vascular Kvβ proteins

V Ohanyan, SM Raph, MM Dwenger, X Hu… - Circulation …, 2021 - Am Heart Assoc
nicotinamide adenine dinucleotide (reduced) (NADH):… and interconversion to pyruvate via
the lactate dehydrogenase … with intracellular pyridine nucleotide redox status 18 ; however, to …

Resveratrol biotransformation and actions on the liver metabolism of healthy and arthritic rats

MS Simões, AP Ames-Sibin, EP Lima, VO Pateis… - Life Sciences, 2022 - Elsevier
… ), reduced β-nicotinamide adenine dinucleotide (NADH; N6005-5G), β-… were measured:
glucose release, lactate and pyruvate … step of gluconeogenesis from lactate in the cytosol and its …

Amylin, tissue hypoxia and metabolic dysregulation in diabetic heart and liver

A Knapton - 2024 - repository.cam.ac.uk
… the cytosol of the cell in glycolysis, producing two pyruvate … gene catalyses the reduction
of pyruvate to lactate, whereas … are accepted by nicotinamide adenine dinucleotide (NAD+) …

Pyruvate dehydrogenase complex, metabolic enzymes, and energy derangement in traumatic brain injury

G Lazzarino, P O'Halloran, V Di Pietro… - … , and Behavioral Aspects …, 2022 - Elsevier
… (including the lactate dehydrogenase reaction). In eukaryotes, glycolysis occurs within cytoplasm
and it … (ATP), 2 mol of reduced nicotinamide adenine dinucleotide (NADH) and 2 mol of …

[HTML][HTML] Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications

S Xie, SC Xu, W Deng, Q Tang - Signal Transduction and Targeted …, 2023 - nature.com
… 2+ uniporter protein, NADH nicotinamide adenine dinucleotide, NCLX mitochondrial Na + /…
of the pyruvate dehydrogenase complex (PDC) from mitochondria to the nucleus triggers the …

Metabolic and redox regulation of cardiovascular stem cell biology and pathology

J Dudek, I Kutschka, C Maack - Antioxidants & Redox Signaling, 2021 - liebertpub.com
… bound protein nicotinamide adenine dinucleotide phosphate … perinuclear localization to the
cell membrane. The ability of … of glucose and the reduction of pyruvate to lactate. To a large …

[HTML][HTML] Associations between local acidosis induced by renal LDHA and renal fibrosis and mitochondrial abnormalities in patients with diabetic kidney disease

DY Lee, JY Kim, E Ahn, JS Hyeon, GH Kim… - Translational …, 2022 - Elsevier
Lactate is generated from pyruvate by LDHA, which … at different speeds to obtain cytosol-
and mitochondria-enriched … the oxidized forms of nicotinamide adenine dinucleotide (NAD) and …

Renal gluconeogenesis: an underestimated role of the kidney in systemic glucose metabolism

D Legouis, A Faivre, PE Cippà… - Nephrology dialysis …, 2022 - academic.oup.com
… We confirmed using transcriptomic data from single-nucleus … and reduced form of nicotinamide
adenine dinucleotide (NAD+/… [71] could inhibit the oxidation of lactate and pyruvate and …