… Because the Ophn1 gene is located on X chromosome, only male mice were used for our
experiments because they develop X-linked ID, while females are not-affected carriers. The …

… Here, we focused on characterizing the syndromic ID gene oligophrenin-1 (OPHN1). We
find that Ophn1 deficiency in mice markedly enhances helpless/depressive-like behavior in the …

… The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation …
X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis…

… in the Oligophrenin 1 gene (OPHN1) cause an X-linked intellectual disability syndrome with
… , and participates in synaptic localization, dendritic spine morphogenesis, AMPA receptor-…

… Here, we studied the effects of high-level NRG1 on dendritic spine … spine morphogenesis
52,53,54 . Downstreams of Rho GTPases include LIMK1, Wiskott–Aldrich syndrome proteins (…

… dendritic spine density and morphology. We found that prenatal treatment with rapamycin
did not recover the decreased density of dendritic spines … Fragile X mental retardation protein …

… , and other interactions with protein partners. Cofilin controls dendritic spine dynamics and
… genetic involvement in NDDs, compared to the X-linked PAK3 gene. The first evidence of a …

… , such as OPHN1 (oligophrenin 1), ARHGEF9 (Cdc42 … DDX3X (DEAD-box helicase 3 X-linked),
coding for an RNA … in neurite outgrowth and dendritic spine formation via modulation of …

… role of these proteins in neuronal morphogenesis, … proteins such as RAPOSTLIN are
explored in dendritic spine formation in rat hippocampal neurons and MIM; for the dendritic spine …

… Mutations in the X-linked ZDHHC9 gene cause cognitive … , despite the clear changes
in OL morphogenesis, we did not … involved in X-linked mental retardation. Nature 392, 923-926 …