… Sirtinol also induces apoptosis in lung cancer … apoptosis [27,31]. Therefore, in the present
study, we evaluated the cytotoxic effect of MHY2245, a sirtinol derivative, on SIRT1/2 inhibition …

… amide structure of sirtinol and shows mild SIRT1 and SIRT2 … SIRT1-3 inhibitor, portrayed
strong antiproliferative effects in … -116 colorectal, and NCI-H23 lung cancer cells. However, JH-…

… We show that SIRT1 modulates the effects of 15d-PGJ 2 and may be used … human lung
adenocarcinoma cell lines were used. All three cell lines were derived from non-small cell lung …

… absence of effect on the acetylation status of the SIRT1 substrates H3K9 … sirtinol, initially
identified as SIRT1/2 inhibitor. 4a inhibits … Both 7b and 7c showed antiproliferative effects in lung …

… non-small cell lung cancer (NSCLC). Sirtinol, a sirtuin (SIRT) 1 and 2 specific inhibitor, is a
… Thus, sirtuins 1 and 2 represent valuable targets for cancer therapy. Recent studies show …

… ] have analyzed the effects of sirtuin inhibition using sirtinol (a non-specific sirtuin inhibitor) on
… In cigarette smoke extract (CSE)-treated human pulmonary microvascular endothelial cells …

… active as micromolar SIRT1/2 inhibitors [IC 50 (SIRT1) = 9.8 µM; IC 50 (SIRT2) = 12.3 µM],
that displays significant antiproliferative and pro-apoptotic properties in several cancer cell …

… induced when SIRT1 is inhibited by expression of dominant-negative SIRT1 or sirtinol and
… , NFATc2 or HIF1α in both human and murine pulmonary artery smooth muscle cells that are …

… of human sirtuins … human sirtuins genes: SIRT1 (AF083106), SIRT2 (AF083107), SIRT3
(AF083108), SIRT4 (AF083109), and SIRT5 (AF083110) [4]. Subsequently, employing human …

… , Sirt2 inhibition with small molecules such as Sirtinol, Cambinol, … , pancreas, breast, oral,
and lung cancer cell lines [58]. It is … effects and the antiproliferative role of piceatannol in cancer. …