Genetics of Alzheimer's disease in the African American population
… difference limits our understanding of the genetic basis of AD in non-EUR populations because
the impact of particular genetic loci … ), different patterns of linkage disequilibrium (LD, ie, …
the impact of particular genetic loci … ), different patterns of linkage disequilibrium (LD, ie, …
A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry
, … Sequencing Project, Alzheimer's Disease Genetic … - … genetics, 2022 - journals.plos.org
… identify the genetic variants that drive this risk difference and … and 4,331 cognitively intact
African American individuals. We … genetic region that includes +/-3 mB around the ApoE gene. …
African American individuals. We … genetic region that includes +/-3 mB around the ApoE gene. …
Apolipoprotein L1 high-risk genotypes and albuminuria in sub-Saharan African populations
JT Brandenburg, MA Govender… - … of the American …, 2022 - journals.lww.com
… differed between and within West and South Africa and were … Almost 50% of the African
American population carries one … African samples for rs60910145 (in linkage disequilibrium with …
American population carries one … African samples for rs60910145 (in linkage disequilibrium with …
Associations of genetically predicted Lp (a)(lipoprotein [a]) levels with cardiovascular traits in individuals of European and African Ancestry
… estimates differed by ancestry, we quantified heterogeneity when combining EA and AA
results for each ASCVD phenotype using I 2 and Cochran Q heterogeneity test (Table 3). I 2 …
results for each ASCVD phenotype using I 2 and Cochran Q heterogeneity test (Table 3). I 2 …
Lipoprotein (a): a genetically determined, causal, and prevalent risk factor for atherosclerotic cardiovascular disease: a scientific statement from the American Heart …
…, American Heart Association Council on … - … , and vascular biology, 2022 - Am Heart Assoc
… the LPA locus strongly associate with Lp(a) levels. Although some are in … linkage disequilibrium
with LPA allele sizes, the associations with Lp(a) levels in plasma differ between different …
with LPA allele sizes, the associations with Lp(a) levels in plasma differ between different …
APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups
S Goyal, Y Tanigawa, W Zhang, JF Chai… - Lipids in Health and …, 2021 - Springer
… We present linkage disequilibrium (LD) using the GIH panel (… In contrast, one African American
carrier from MISS_OLIVER … Perhaps, because of these differences, we and other studies …
carrier from MISS_OLIVER … Perhaps, because of these differences, we and other studies …
Genetic associations between serum low LDL-cholesterol levels and variants in LDLR, APOB, PCSK9 and LDLRAP1 in African populations
… Studies in African Americans have replicated some of these … linkage disequilibrium in African
populations [19–25]. However, … Using a different cohort from West Africa, we replicated the …
populations [19–25]. However, … Using a different cohort from West Africa, we replicated the …
[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene
S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
… He described both the apolipoprotein E polymorphism and the … Multiple levels of linkage
disequilibrium between … [65], likely reflecting differences in the genetic ancestry at the LPA locus. …
disequilibrium between … [65], likely reflecting differences in the genetic ancestry at the LPA locus. …
Novel Alzheimer disease risk loci and pathways in African American individuals using the African genome resources panel: a meta-analysis
… cassette transporter (ABCA7), apolipoprotein E ϵ4,and the … to these observed ancestral
differences in disease risk, we … in the same linkage disequilibrium block as the African American …
differences in disease risk, we … in the same linkage disequilibrium block as the African American …
Candidate Gene Analysis Reveals Strong Association of CETP Variants With High Density Lipoprotein Cholesterol and PCSK9 Variants With Low Density …
… identified three novel variants in linkage disequilibrium in … of 10,903 individuals from six
different sites of which our study … lipid trait GWAS loci in African Americans and strengthen the …
different sites of which our study … lipid trait GWAS loci in African Americans and strengthen the …