Nucleoid-associated proteins shape chromatin structure and transcriptional regulation across the bacterial kingdom

HM Amemiya, J Schroeder, PL Freddolino - Transcription, 2021 - Taylor & Francis
Nucleoid associated proteins mediate a variety of DNA … HUα E34K , a HupA variant that
inhibits the formation of … HU is critical for remodeling of the nucleoid through various phases of …

Addressing the possibility of a histone-like code in bacteria

VJ Carabetta - Journal of proteome research, 2020 - ACS Publications
… In bacteria, nucleoid-associated proteins (NAPs) are … effect on chromatin structure by
influencing proteinDNA interactions. … of HupA from the distantly related, spiral shaped, cell-wall-…

[HTML][HTML] Nucleoid remodeling during environmental adaptation is regulated by HU-dependent DNA bundling

SG Remesh, SC Verma, JH Chen, AA Ekman… - Nature …, 2020 - nature.com
… organization activities of nucleoid-associated proteins (NAPs) is … global organization of the
bacterial chromatin (reviewed in ref. ). … at the hupA locus and a wild-type copy of hupA gene …

Nucleoid-Associated Proteins Undergo Liquid-Liquid Phase Separation with DNA into Multiphasic Condensates Resembling Bacterial Nucleoids

A Gupta, A Joshi, K Arora, S Mukhopadhyay… - BioRxiv, 2022 - biorxiv.org
… key Nucleoid Associated Proteins (NAP) that could be responsible for causing DNA to enter
… The remodeling is suggestive of fusion and separation of bead-like entities, partitioning and …

[HTML][HTML] Small prokaryotic DNA-binding proteins protect genome integrity throughout the life cycle

K Molan, D Žgur Bertok - International journal of molecular sciences, 2022 - mdpi.com
DNA into nucleosomes, all bacterial species possess abundant small proteins designated
nucleoid-associated proteins … [23], whereas Clostridium difficile harbors only a hupA gene [24]. …

Non‐specific and specific DNA binding modes of bacterial histone, HU, separately regulate distinct physiological processes through different mechanisms

SC Verma, A Harned, K Narayan… - Molecular …, 2023 - Wiley Online Library
… that HU associates with the nucleoid mostly through non-… and variant HUα 2 proteins with
a relaxed plasmid DNA made by … DNA binding proteins such as the yeast chromatin protein

Enhanced binding of an HU homologue under increased DNA supercoiling preserves chromosome organisation and sustains Streptomyces hyphal growth

A Strzałka, A Kois-Ostrowska, M Kędra… - Nucleic Acids …, 2022 - academic.oup.com
Bacterial chromosome topology is controlled by topoisomerases and nucleoid-associated
proteins (… We verified that HupA has an increased affinity for supercoiled DNA in vivo and in …

Stress-induced nucleoid remodeling in Deinococcus radiodurans is associated with major changes in Heat Unstable (HU) protein dynamics

P Vauclare, J Wulffelé, F Lacroix, P Servant… - Nucleic Acids …, 2024 - academic.oup.com
… on the diversity of nucleoid remodeling processes in bacteria and … HupA is a conventional
HU protein similar to the … that the chromatin decondenses in response to DNA damage to …

Functional and Mechanistic Characterization of Heterochromatin-like Domains in Bacteria

H Amemiya - 2021 - deepblue.lib.umich.edu
Nucleoid associated proteins mediate a variety of DNANucleoid remodeling during
environmental adaptation is … in the organization and compaction of bacterial chromatin. Mol …

[HTML][HTML] Composition of transcription machinery and its crosstalk with nucleoid-associated proteins and global transcription factors

G Muskhelishvili, P Sobetzko, S Mehandziska… - Biomolecules, 2021 - mdpi.com
… and composition of abundant chromatin architectural proteins—was dubbed … bacterial
genome [61,95] and the observed activation of hupA, as opposed to hupB, by DNA relaxation can