[HTML][HTML] Surfactant replacement therapy: from biological basis to current clinical practice

R Hentschel, K Bohlin, A van Kaam, H Fuchs… - Pediatric …, 2020 - nature.com
… This review summarizes the current knowledge on the physiological action of endogenous
and exogenous pulmonary surfactant, the role of different types of animal-derived and …

[HTML][HTML] A recipe for a good clinical pulmonary surfactant

J Pérez-Gil - biomedical journal, 2022 - Elsevier
current concepts on the compositional and structural determinants defining pulmonary
surfactant … -derived or recombinant or synthetic therapeutic surfactants, as well as a the most …

[HTML][HTML] Structural hallmarks of lung surfactant: Lipid-protein interactions, membrane structure and future challenges

JC Castillo-Sánchez, A Cruz, J Pérez-Gil - Archives of biochemistry and …, 2021 - Elsevier
Lung surfactant (LS) is an outstanding example of how a highly regulated and dynamic …
stabilizes the respiratory air-liquid interface in the mammalian lung. The present review dissects …

Pulmonary surfactant: a mighty thin film

F Possmayer, YY Zuo, RAW Veldhuizen… - Chemical …, 2023 - ACS Publications
pulmonary surfactantpulmonary surfactant stabilizes our alveoli has still not been achieved.
It has long been suggested (but not always accepted) that the ability of pulmonary surfactant

Recent progress on surfactant protein A: cellular function in lung and kidney disease development

SD King, SY Chen - American Journal of Physiology-Cell …, 2020 - journals.physiology.org
… In this mini-review, we discuss SP-A functions and the consequences of SP-A genetic
mutations or pulmonary surfactant deficiencies, with a specific emphasis on the recent progress in …

[HTML][HTML] The Past and Future of Genetics in Pulmonary Disease-You Can Teach an Old Dog New Tricks

LM Nogee, A Hamvas - Pediatric pulmonology, 2020 - ncbi.nlm.nih.gov
… As an example, genetic disorders of surfactant metabolism result … respiratory failure to adult
onset pulmonary fibrosis (1-7). The lung histopathology diagnoses associated with surfactant

[HTML][HTML] Fluid Films as Models for Understanding the Impact of Inhaled Particles in Lung Surfactant Layers

E Guzmán - Coatings, 2022 - mdpi.com
… Once pollutants enter the alveolar cavity, they are deposited on the lung surfactant (LS) film,
altering their mechanical performance which increases the respiratory work and can induce …

[HTML][HTML] Engineering of pulmonary surfactant corona on inhaled nanoparticles to operate in the lung system

M Falahati, A Hasan, HA Zeinabad, V Serpooshan… - Nano Today, 2023 - Elsevier
lung tissue results in the adsorption of pulmonary surfactant (… phospholipids (PLs) and
surfactant proteins (SPs) provides NPs … in lung environment. First, the physiological barriers in the …

[HTML][HTML] Alveolar lipids in pulmonary disease. A review

CW Agudelo, G Samaha, I Garcia-Arcos - Lipids in health and disease, 2020 - Springer
… In vitro and ex vivo experiments with clinically used surfactant and with simplified model
phospholipid mixtures have shown the coexistence of two domains in the pulmonary surfactant

[HTML][HTML] Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook

JA Moura, K Meldrum, SH Doak, MJD Clift - … Cell & Developmental Biology, 2023 - Elsevier
… towards the lung’s defense, as well as being important components of lung surfactant [9]. In
… lamellar bodies which contain and secrete lung surfactant (surfactant proteins A, B, and D) […