… major effects induced by C3a or C4a on neutrophil functions. By contrast, exposure to C5a or
C5a … Similarly, C5a and C5a des-Arg but no other monitored complement cleavage product …

… also have an important role maintaining homeostasis in … neutrophil chemoattractant C5a
4,69 . Neutrophils primed by … model of neutrophil-mediated vascular inflammation could …

… have previously reported an important role of this receptor in … pathogenesis of
neutrophil-mediated autoimmune diseases. … our in vitro data analyzing the C5a and Fcγ …

… involved, C5a, the most potent anaphylatoxin of our immune system, plays a key role. Therefore,
… for the treatment of C5a-dependent neutrophil-driven (autoimmune) diseases like EBA. …

… critical role in COVID-19 pneumonia (29, 34–36). Altogether, these data point toward a
possible role for C5a in the hyperactivation of neutrophils in the lungs of patients with COVID-19. …

… its crucial role in the immune system-mediated protection from internal and external threats,
C5a … Rheumatoid Arthritis (RA) is a systemic autoimmune disease that affects 0.24% of the …

… , but also plays a major role in stimulating the adaptive immune … and C5a are small
anaphylatoxins, mediating pro-inflammatory … This systemic autoimmune disease is characterized …

… of C3a and C5a-triggered inflammation abrogates neutrophil … of C3 inhibitors to intercept
neutrophil-mediated, NET-driven … COVID-19 biopsies argues for a key role of these pathways [4,…

… –C), suggesting an important role for SVMP in complement … generation of C5a or sTCC, we
decided to evaluate the role of … of a plethora of inflammatory, autoimmune, and degenerative …

… roles in inflammatory diseases, we investigated whether C5a/C5aR1 pathway could be
involved in COVID-19 pathophysiology. C5a/… , especially in neutrophils of critically ill COVID-19 …