… Three deiodinase selenoenzymes control local availability of T3 to … Iodothyronine deiodinases
(DIO) are a family of … -spatial expression, regulation and function and exhibit different …

… the deiodinase-mediated (in-)activation of thyroid hormones, … ago as the second selenoprotein
family after glutathione … synthesis of DIOs and other crucial selenoenzymes (eg, GPX4, …

… thyroid gland and are involved in different processes, such as the formation and regulation
of THs (the iodothyronine deiodinases (DIO) family… more abundant selenoenzymes acting at …

… thyroid hormone action, and the cloning of the 3 deiodinase … and those encoding another
selenoenzyme, glutathione … selenodeiodinase family, as had been widely assumed (59). …

… for the thyroid hormone (TH) axis (> 1000 hits for “selenium & … the 3 Sec-containing
deiodinases, and the pathogenetic role … that the 3 DIO selenoenzymes together control both local …

… deiodinases, the enzymes responsible for homeostasis and for controlling the activity of
thyroid hormones … Selenoproteins such as those belonging to the GPx and TrxR families—which …

… These actions depend on provision of thyroid hormones in … (DIO1, DIO2, and DIO3,
respectively) are selenoenzymes with … Two families have been identified that carry heterozygous …

… expression in liver and kidney, including deiodinase type 1. … to thyroid function, TH biosynthesis,
and/or TH action on … of T4 to T3 by the selenoenzymes Dio is critical for the pre-receptor …

… The amount of T3 available for binding to the receptors is regulated by cell specific
expression of deiodinases (DIOs), a family of selenoenzymes. DIO1 and DIO2 catalyze the …

… thyroid hormone-metabolizing enzymes that are deiodinases… as the catalytic sites of the
selenoenzyme. Mechanistically, … failure to thrive was observed, while Family 4, arguably the most …