[HTML][HTML] Chronic Fluoxetine Impairs the Effects of 5-HT1A and 5-HT2C Receptors Activation in the PAG and Amygdala on Antinociception Induced by Aversive …

D Baptista-de-Souza, LRR Tavares… - Frontiers in …, 2020 - frontiersin.org
… Therefore, we hypothesized that chronic treatment with fluoxetine alters the role of 5-HT
1A and 5-HT 2C receptors located in the amygdaloid complex and PAG in the modulation of …

Phytoconstituents Targeting the Serotonin 5-HT3 Receptor: Promising Therapeutic Strategies for Neurological Disorders

L Akotkar, U Aswar, A Ganeshpurkar… - ACS Pharmacology & …, 2024 - ACS Publications
… 5-HT and its receptors play a crucial role in developing gastric … zerumbet exert their
antinociceptive effects by modulating the l-… that 5-HT1 and 5-HT2, rather than 5-HT3R, receptors

[HTML][HTML] Niclosamide: A Potential Antipruritic Agent by Modulating Serotonin Pathway through Metabotropic glutamate receptors.

ZE Soltani, M Elahi, MA Rad, S Farsio, AR Dehpour - Heliyon, 2024 - cell.com
… systems, while the other subtypes mostly exhibit antinociceptive functions ( … effects on the
expression of 5-HT2, mGluR1, mGluR5, and TRPV1. While there are several studies on the role

[HTML][HTML] The role of psychiatric, analgesic, and antiepileptic medications in chronic pruritus

P Patel, K Patel, K Pandher, RS Tareen - Cureus, 2021 - ncbi.nlm.nih.gov
… given 20 mg of the SSRI paroxetine once every morning for a … by the antagonism of 5-HT2
and 5-HT3 reuptake receptors. … , which have antinociceptive properties. The antihistamine …

Defensive and emotional behavior modulation by serotonin in the periaqueductal gray

P Vázquez-León, A Miranda-Páez… - Cellular and Molecular …, 2023 - Springer
… It is proposed that PAG plays an integrating role in aversive … discuss the involvement of
other receptors and brain nuclei to … to the clinical role of serotonin in various mental disorders. …

The roles of serotonin in neuropsychiatric disorders

M Pourhamzeh, FG Moravej, M Arabi… - Cellular and molecular …, 2022 - Springer
… The serotonergic system also plays roles in modulating various other ligands, including … a
wide range of biological functions, we herein first describe 5-HT’s role in the CNS, specifically …

[HTML][HTML] Multiple modulatory roles of serotonin in chronic pain and injury-related anxiety

S Hao, W Shi, W Liu, QY Chen, M Zhuo - Frontiers in Synaptic …, 2023 - frontiersin.org
… As reported, the 5-HT 7 receptor agonist AS-19 exerted a dose-dependent antinociceptive
effect … It was also reported that the microinjection of SSRI paroxetine into the S1, a key cortical …

[HTML][HTML] The role of serotonergic and catecholaminergic systems for possible antidepressant activity of apigenin

MJ Al-Yamani, SMB Asdaq, AS Alamri… - Saudi Journal of …, 2022 - Elsevier
… ondansetron (5-HT3 receptor antagonist) signifying the possible role of 5-HT3 receptor in
potential … The antinociceptive effect of trazodone in mice is mediated through both μ-opioid and …

[HTML][HTML] Functional dimerization of serotonin receptors: role in health and depressive disorders

EV Mitroshina, EA Marasanova… - International journal of …, 2023 - mdpi.com
receptors (5-HTR), notably 5-HT1A and 5-HT2, in mediating the morphogenic effects
With the exception of serotonin type 3 (5-HT3) receptors, which function as ligand-gated ion …

Trazodone and mirtazapine: A possible opioid involvement in their use (at low dose) for sleep?

S Schreiber, CG Pick - Medical Hypotheses, 2020 - Elsevier
antinociceptive effect of trazodone is influenced by the opioid … This program maximizes the
log-likelihood function to fit a … blocks specifically the 5-HT2 and 5-HT3 type receptors, while …