[HTML][HTML] Pathobiology of the klotho antiaging protein and therapeutic considerations

GJ Prud'homme, M Kurt, Q Wang - Frontiers in Aging, 2022 - frontiersin.org
… multiple Wnt ligands are able to bind to the cognate receptor, … and/or anti-inflammatory
effect. In addition, recombinant … , metformin and peroxisome proliferator-activated receptors γ …

[PDF][PDF] The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition

ESA Arafa, MS Refaey, OAM Abd El-Ghafar… - Heliyon, 2021 - cell.com
… the level of peroxisome proliferator-activated receptor gamma (PPARγ… The anti-inflammatory
and antioxidative effects of … decrease the receptor activator of nuclear factor kappa-В ligand (…

New insights into the role and therapeutic potential of HSP70 in diabetes

AA de Oliveira, VO Mendoza, S Rastogi… - Pharmacological …, 2022 - Elsevier
… islets, which can be prevented by an inhibitor of TLR2/TLR4, … (c) inhibits peroxisome
proliferator-activated receptor (PPAR)-… switching of HSP70 from an anti-inflammatory (iHSP70) to a …

Phytochemistry and Pharmacological Aspects of Apigenin: A Review

H Bhardawaj, N Vasudeva… - The Natural Products …, 2023 - ingentaconnect.com
… and also reduced streptozotocin-induced oxidative damage in … , anti-inflammatory, and
anti-oxidative medicines can success… to be linked to increasing peroxisome proliferator activated

Adiponectin synthesis, secretion and extravasation from circulation to interstitial space

SC da Silva Rosa, M Liu, G Sweeney - Physiology, 2021 - journals.physiology.org
anti-inflammatory action and subsequent insulin-sensitizing … include the peroxisome
proliferatoractivated receptor (PPAR)… -length adiponectin in streptozotocin-induced diabetic mice, …

Anti-Diabetic Therapy and Heart Failure: Recent Advances in Clinical Evidence and Molecular Mechanism

CN Hsu, CF Hsuan, D Liao, JKJ Chang, AJW Chang… - Life, 2023 - mdpi.com
… synthetic ligands of peroxisome proliferator-activated receptors … of cardiac energy metabolism
and antioxidant proteins [138]. … anti-inflammatory effects also contributed to the inhibition of …

Pharmacology of apocynin: a natural acetophenone

SR Savla, AP Laddha, YA Kulkarni - Drug metabolism reviews, 2021 - Taylor & Francis
… products (AGEs), and the activating ligands for the same, (iii) … drinking water to
streptozotocin-induced diabetic mice leads to … inhibition of NOX 2 promotes activation of …

Mitochondrial regulation of diabetic endothelial dysfunction: pathophysiological links

X Fang, Y Zhang, H Wu, H Wang, R Miao, J Wei… - … International Journal of …, 2024 - Elsevier
… , anti-inflammatory and pro-inflammatory responses, … PGC1α, peroxisome proliferator-activated
receptor gamma coactivator … microvessels from streptozotocin-induced diabetic rats were …

[PDF][PDF] Beneficial Effect of Lycopene on Diabetes Mellitus and its Possible Mechanism: A Review: doi. org/10.26538/tjnpr/v5i3. 2

H Goenawan, YS Pratiwi, NP Dewi… - Tropical Journal of …, 2021 - researchgate.net
… Moreover, lycopene also has anti-inflammatory effects. Many … some literature reporting that
ligand binding to RAGE triggers … in the hippocampus of streptozotocin-induced diabetic rats. …

Diffuse myocardial fibrosis: mechanisms, diagnosis and therapeutic approaches

B López, S Ravassa, MU Moreno, GS José… - Nature Reviews …, 2021 - nature.com
… that acts as a receptor for various ligands in different cell types) … endothelium and the inhibition
of lymphangiogenesis delay … and increases the expression and secretion of collagen and …