A multidisciplinary journey towards bone tissue engineering

SG Pedrero, P Llamas-Sillero, J Serrano-López - Materials, 2021 - mdpi.com
… In this context, the traditional routes to address bone disorders … are embryonic stem cells,
induced pluripotent stem cells, … , allowing attachment of actin filaments and microtubules to the …

Biomechanical cues as master regulators of hematopoietic stem cell fate

H Li, Q Luo, W Shan, S Cai, R Tie, Y Xu, Y Lin… - Cellular and Molecular …, 2021 - Springer
… generation of definitive hematopoietic cells in vitro from embryonic stem cells (ESCs) … actin
and myosin proteins into anisotropic contractile circumferential actomyosin around stem cells […

Keratins are asymmetrically inherited fate determinants in the mammalian embryo

HYG Lim, YD Alvarez, M Gasnier, Y Wang, P Tetlak… - Nature, 2020 - nature.com
… that mitotic cells display a dense cytoplasmic F-actin meshwork … Disrupting the F-actin
meshwork using cytochalasin D … , according to animal ethics guidelines of the Agency for Science, …

Cell stiffness under small and large deformations measured by optical tweezers and atomic force microscopy: effects of actin disruptors CK-869 and jasplakinolide

ŠZ Jokhadar, J Iturri, JL Toca-Herrera… - Journal of Physics D …, 2021 - iopscience.iop.org
… , yet, in our set-up, they differed significantly in the direction of the indentation and the … In
addition, these effects will depend on the contact area between the indenting probe and the …

Elimination of teratogenic human induced pluripotent stem cells by bee venom via calcium-calpain pathway

A Kim, SY Lee, BY Kim, SK Chung - International journal of molecular …, 2020 - mdpi.com
… shown to support human embryonic stem cell survival, substrate … Because we found that BV
disrupted F-actin organization … agent, we are currently investigating the beneficial effects of …

[PDF][PDF] Impact of environmental neurotoxic: current methods and usefulness of human stem cells

A Rosca, R Coronel, M Moreno, R González, A Oniga… - Heliyon, 2020 - cell.com
… attention as possible therapeutic agents or as disease … , as well as guidelines on how to use
them to address the specificity, … stem cells (PSCs), human embryonic stem cells (hESCs) and …

Microtubule targeting agents in disease: classic drugs, novel roles

L Wordeman, JJ Vicente - Cancers, 2021 - mdpi.com
… tumor vasculature using vascular-disrupting agents (VDAs). … actin cytoskeleton. Thus, small
changes in MT dynamics could … for cell invasion, where cells were placed in contact with …

Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips

N Huebsch, B Charrez, G Neiman, B Siemons… - Nature biomedical …, 2022 - nature.com
… Culturing hiPSC-CM or human embryonic stem cell-derived … To address this hypothesis,
we tested fatty-acid-based MM in … effects of flecainide at doses that significantly disrupted

The effect of endocrine-disrupting chemicals on placental development

Y Yan, F Guo, K Liu, R Ding, Y Wang - Frontiers in endocrinology, 2023 - frontiersin.org
… is active, direct contact with pesticide application and nutrition … worldwide pollutants by the
Agency for Toxic Substances and … significant knowledge gaps that will guide future research. …

Cytoskeletal dynamics in epithelial-mesenchymal transition: insights into therapeutic targets for cancer metastasis

A Datta, S Deng, V Gopal, KCH Yap, CE Halim, ML Lye… - Cancers, 2021 - mdpi.com
… junctions to strengthen epithelial cell-cell contact [27]. Hence, … , results in disruption of cell-cell
adhesion and formation of … have pivoted their direction from actin to actin-binding proteins …