Piperacillin-tazobactam in intensive care units: a review of population pharmacokinetic analyses

I El-Haffaf, JA Caissy, A Marsot - Clinical pharmacokinetics, 2021 - Springer
antibacterial activity of piperacillin-tazobactam. Many studies used various targets for their
simulations, as represented in Table 6. The two most frequent targets were 100% fT > MIC , …

[PDF][PDF] Clinical Pharmacology of Piperacillin/Tazobactam

GM Pacifici - J. Clin. Biomed. Investig, 2023 - respubjournals.com
… , piperacillin extends the spectrum of activity of ampicillin and combined with tazobactam,
piperacillin/ tazobactam … A review of its antibacterial activity, pharmacokinetic properties and …

An integral pharmacokinetic analysis of piperacillin and tazobactam in plasma and urine in critically ill patients

E Wallenburg, R Ter Heine, JA Schouten… - … pharmacokinetics, 2022 - Springer
… the pharmacokinetics of both piperacillin and tazobactam in … pharmacokinetic model for
both piperacillin and tazobactam … of piperacillin and tazobactam pharmacokinetics and urinary …

Population pharmacokinetics of piperacillin/tazobactam across the adult lifespan

M Hemmersbach-Miller, SJ Balevic, PL Winokur… - … pharmacokinetics, 2023 - Springer
Piperacillin/tazobactam is one of the most frequently used antimicrobials in older adults…
pharmacokinetics of piperacillin/tazobactam as a probe drug to evaluate changes in antibacterial

Pharmacokinetics and Pharmacodynamics of High-Dose PiperacillinTazobactam in Obese Patients

JJ Veillette, SA Winans, VK Maskiewicz… - … and Pharmacokinetics, 2021 - Springer
… re-growth or a minimum killing effect was seen even at 2 mg/L … tazobactam concentrations
enhance piperacillin activity against Gram-negative isolates [27,28,29]. Regarding piperacillin, …

Time above the MIC of piperacillin-tazobactam as a predictor of outcome in Pseudomonas aeruginosa bacteremia

E Tannous, S Lipman, A Tonna, E Hector… - Antimicrobial agents …, 2020 - Am Soc Microbiol
pharmacokinetic-pharmacodynamic index associated with in vitro maximal bacterial killing for
piperacillin-tazobactam … , like other β-lactams, exhibits time-dependent bactericidal activity. …

Population pharmacokinetics of continuous infusion of piperacillin/tazobactam in very elderly hospitalized patients and considerations for target attainment against …

PG Cojutti, E Morandin, M Baraldo, F Pea - … journal of antimicrobial agents, 2021 - Elsevier
… (TAZ), a beta-lactamase inhibitor that may extend antibacterial activity against extended-…
Like other beta-lactams, PIP has time-dependent antibacterial activity, and the time that the …

Population pharmacokinetics of piperacillin and tazobactam in critically ill patients receiving extracorporeal membrane oxygenation: an ASAP ECMO study

V Cheng, MH Abdul-Aziz, F Burrows… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
pharmacokinetics (PK) of piperacillin and tazobactam in patients … Serial piperacillin and
tazobactam plasma concentrations were … Piperacillin exhibits time-dependent bactericidal activity

Population pharmacokinetics of piperacillin/tazobactam in critically ill Korean patients and the effects of extracorporeal membrane oxygenation

YK Kim, HS Kim, S Park, H Kim… - … of Antimicrobial …, 2022 - academic.oup.com
… PK model of piperacillin/tazobactam that is suitable … effects of ECMO on piperacillin/tazobactam
PK. Moreover, we investigated appropriate dosage regimens of piperacillin/tazobactam

… of Different Piperacillin-Tazobactam Dosage Regimens on Synergy of the Combination with Tobramycin against Pseudomonas aeruginosa for the Pharmacokinetics …

JR Tait, H Bilal, KE Rogers, Y Lang, TH Kim, J Zhou… - Antibiotics, 2022 - mdpi.com
… We evaluated piperacillin-tazobactam and tobramycin … kill studies (SCTK) assessed
piperacillin-tazobactam and tobramycin … ) investigated isolates Pa1281 (MIC piperacillin 4 mg/L, …