… T cells are widely considered to be major contributors to inflammatory demyelination in
MS, growing evidence suggests a significant role for B cells … thought to underlie B-cell–mediated …

… functions in MS. In this review, we summarize the importance of B cells in MS and discuss the
different B cell … -inflammatory functions and how therapies modulate B cell functions in MS …

… evidence indicates the involvement of B cells in the pathogenesis of multiple sclerosis (MS),
but their precise roles are … functions of B cells and the main mechanisms through which …

… role for B cells in MS patients. The results from this treatment put forward T-cell activation rather
than antibody production by B cells as … interaction provokes both B and T cells to infiltrate …

… overview of B cell function in both MS patients and animal models of the disease. We will
explore the contribution of B cells to the pathogenesis of cortical lesions, including their role in …

… including B-cell biology and the role of B-cells in triggering autoimmune neuroinflammation
with a focus on the regulation of antibody-producing B-cells. We will then discuss the role of …

… experiments to help an understanding of multiple sclerosis (MS) biology. … B cell subsets
as important mediators in MS. The trial of tabalumab (NTC00882999), which inhibits B cell …

… , the landscape of cells of the adaptive immune system that are believed to play a role in MS
… not only CD4 T helper cells but also cytotoxic CD8 T cells and B cells. Once the key cellular …

… B cell depletion via anti-CD20 antibodies is a highly effective treatment for multiple sclerosis
(MS)… However, little is known about the maturation/activation stage of the returning B cell …

… This is emphasized in multiple sclerosis, in which B cell-depleting therapies are arguably
the most efficacious treatment for the condition. In this Review, we discuss how …