… The 4 phases of ALI/ARDS follow a predictable pattern that … Given the important role that
surfactant and its loss at the … As we look toward the future of pharmacologic intervention there …

… pro-inflammatory mediators in ALI/ARDS at the mRNA level 19 … pulmonary route for the
treatment of ALI/ARDS and we discuss … a great impact on ALI/ARDS since surfactant production is …

… can impair surfactant layer composition and function, while … Citation65 Moreover, early
surfactant administration resulted … In future large clinical trials, factors such as dosing, delivery …

… We summarize JAK and STAT inhibitors with ARDS treatment … future trends in the design
of JAK inhibitors, which will help to develop effective treatment strategies for ARDS in the future. …

… 60% FiO 2 with PEEP of at least 5 cmH 2 O for at least 16 h until … Findings on the impact of
surfactants on mortality in ARDS … for the future of ARDS to find effective therapies. Another new …

… key regulators of tissue repair during ALI/ARDS recovery (63, 64). … studies are still needed
to confirm this idea in the future. … with surfactant protein B enhanced the repair of ALI/ARDS by …

… by ALI/ARDS, effective treatment strategies for ALI/ARDS are still … future design of
nanomedicines for siRNA inhalation therapy. … Schematic representation of siNGs coated with …

… The future of ARDS therapy will go through phenotyping that … Phospholipases A2
inhibitors and surfactant therapies … Surfactant therapies might be of concern for pediatric (PARDS) …

… be considered during trial design to target specific therapies to … to treatments is crucial for
future developments [Citation66]. … of patients who might benefit from surfactant administration. …

… during the onset of ARDS/ALI can help elucidate the mechanisms underlying ARDS/ALI
pathogenesis and serve as the basis for the development of new treatment … for future research. …