Genomics of hypertension: the road to precision medicine

S Padmanabhan, AF Dominiczak - Nature Reviews Cardiology, 2021 - nature.com
… -wide association studies (GWAS) as being associated with the blood pressure phenotype
explain only … of known genetic factors involved in blood pressure-regulating pathways in that …

Role of inflammatory chemokines in hypertension

TP Mikolajczyk, P Szczepaniak, F Vidler… - Pharmacology & …, 2021 - Elsevier
… for blood pressure regulation and mediate target organ damage, creating unique novel targets
… have tested the efficacy of pharmacological or genetic targeting of chemokines and their

Estrogen-related mechanisms in sex differences of hypertension and target organ damage

AR Sabbatini, G Kararigas - Biology of sex differences, 2020 - Springer
blood pressure (BP) in both men and women, reaching 63.1% among adults aged 60 years
and over, and it … adipogenesis-related genes [77], as well as the up-regulation of peroxisome …

Arterial hypertension

S Brouwers, I Sudano, Y Kokubo, EM Sulaica - The Lancet, 2021 - thelancet.com
… genome-wide association studies on blood pressure traits (… in blood pressure. The discovery
of novel loci has clarified new mechanisms of blood pressure regulation and the association

Blood pressure and risk of cancer: a Mendelian randomization study

II Chan, MK Kwok, CM Schooling - BMC cancer, 2021 - Springer
… replicated genetic instruments for systolic and diastolic BP to summary genetic associations
… a meta-analysis of genome-wide association studies (GWAS) for BP traits totaling 757,601 …

Advancing the use of genome-wide association studies for drug repurposing

WR Reay, MJ Cairns - Nature Reviews Genetics, 2021 - nature.com
genes and pathways that can be pharmacologically modulated, transcriptome-wide association
studies, gene-set association… on blood pressure in randomized controlled trials 7,32,33 . …

Association of antihypertensive drug target genes with psychiatric disorders: a Mendelian randomization study

S Chauquet, Z Zhu, MC O'Donovan… - JAMA …, 2021 - jamanetwork.com
… from published case-control genome-wide association studies (sample 2). Significant … to
identify suitable genetic instruments for blood pressure–lowering drug target gene expression (…

The two faces of ACE2: the role of ACE2 receptor and its polymorphisms in hypertension and COVID-19

M Bosso, TA Thanaraj, M Abu-Farha… - … Therapy Methods & …, 2020 - cell.com
genetic association studies have examined the relationship between ACE2 genetic variants
and the risk of developing hypertension in … blood pressure and maintains blood pressure

White blood cells and blood pressure: a Mendelian randomization study

M Siedlinski, E Jozefczuk, X Xu, A Teumer… - Circulation, 2020 - Am Heart Assoc
… Well-powered, genome-wide association studies (GWAS) … assessment of genetic association
between BP and blood cell … , we aimed to identify a target organ, whose function is causal …

Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies

J Zhang, D Dutta, A Köttgen, A Tin, P Schlosser… - Nature Genetics, 2022 - nature.com
… We replicated cis-pQTL discovered in the ARIC AA in the AASK—a clinical trial of alternate
blood pressure lowering regimen and goals 35 . Enrollment occurred from 1995 to 1998, with …