Genomics of hypertension: the road to precision medicine
S Padmanabhan, AF Dominiczak - Nature Reviews Cardiology, 2021 - nature.com
… -wide association studies (GWAS) as being associated with the blood pressure phenotype
explain only … of known genetic factors involved in blood pressure-regulating pathways in that …
explain only … of known genetic factors involved in blood pressure-regulating pathways in that …
Role of inflammatory chemokines in hypertension
TP Mikolajczyk, P Szczepaniak, F Vidler… - Pharmacology & …, 2021 - Elsevier
… for blood pressure regulation and mediate target organ damage, creating unique novel targets
… have tested the efficacy of pharmacological or genetic targeting of chemokines and their …
… have tested the efficacy of pharmacological or genetic targeting of chemokines and their …
Estrogen-related mechanisms in sex differences of hypertension and target organ damage
AR Sabbatini, G Kararigas - Biology of sex differences, 2020 - Springer
… blood pressure (BP) in both men and women, reaching 63.1% among adults aged 60 years
and over, and it … adipogenesis-related genes [77], as well as the up-regulation of peroxisome …
and over, and it … adipogenesis-related genes [77], as well as the up-regulation of peroxisome …
Arterial hypertension
S Brouwers, I Sudano, Y Kokubo, EM Sulaica - The Lancet, 2021 - thelancet.com
… genome-wide association studies on blood pressure traits (… in blood pressure. The discovery
of novel loci has clarified new mechanisms of blood pressure regulation and the association …
of novel loci has clarified new mechanisms of blood pressure regulation and the association …
Blood pressure and risk of cancer: a Mendelian randomization study
II Chan, MK Kwok, CM Schooling - BMC cancer, 2021 - Springer
… replicated genetic instruments for systolic and diastolic BP to summary genetic associations
… a meta-analysis of genome-wide association studies (GWAS) for BP traits totaling 757,601 …
… a meta-analysis of genome-wide association studies (GWAS) for BP traits totaling 757,601 …
Advancing the use of genome-wide association studies for drug repurposing
… genes and pathways that can be pharmacologically modulated, transcriptome-wide association
studies, gene-set association… on blood pressure in randomized controlled trials 7,32,33 . …
studies, gene-set association… on blood pressure in randomized controlled trials 7,32,33 . …
Association of antihypertensive drug target genes with psychiatric disorders: a Mendelian randomization study
… from published case-control genome-wide association studies (sample 2). Significant … to
identify suitable genetic instruments for blood pressure–lowering drug target gene expression (…
identify suitable genetic instruments for blood pressure–lowering drug target gene expression (…
The two faces of ACE2: the role of ACE2 receptor and its polymorphisms in hypertension and COVID-19
… genetic association studies have examined the relationship between ACE2 genetic variants
and the risk of developing hypertension in … blood pressure and maintains blood pressure …
and the risk of developing hypertension in … blood pressure and maintains blood pressure …
White blood cells and blood pressure: a Mendelian randomization study
M Siedlinski, E Jozefczuk, X Xu, A Teumer… - Circulation, 2020 - Am Heart Assoc
… Well-powered, genome-wide association studies (GWAS) … assessment of genetic association
between BP and blood cell … , we aimed to identify a target organ, whose function is causal …
between BP and blood cell … , we aimed to identify a target organ, whose function is causal …
Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies
… We replicated cis-pQTL discovered in the ARIC AA in the AASK—a clinical trial of alternate
blood pressure lowering regimen and goals 35 . Enrollment occurred from 1995 to 1998, with …
blood pressure lowering regimen and goals 35 . Enrollment occurred from 1995 to 1998, with …