Genomic alterations and tumor mutation burden in Merkel cell carcinoma
Importance Merkel cell carcinoma (MCC) is a rare and highly aggressive cutaneous
neuroendocrine carcinoma with increasing incidence. Cytotoxic chemotherapy and checkpoint …
neuroendocrine carcinoma with increasing incidence. Cytotoxic chemotherapy and checkpoint …
[HTML][HTML] Biomarker-driven prognostication in Merkel cell carcinoma: a paradigm for personalized therapy
BA Helmink, G Ansstas, RC Fields - Annals of surgical oncology, 2022 - Springer
… While the diagnosis of Merkel cell carcinoma (MCC) is rare, the incidence has almost
doubled in the United States since 2000. Moreover, when MCC has spread beyond the primary …
doubled in the United States since 2000. Moreover, when MCC has spread beyond the primary …
[HTML][HTML] An updated review of the biomarkers of response to immune checkpoint inhibitors in Merkel cell carcinoma: Merkel cell carcinoma and immunotherapy
… the TMB-H observed in Merkel cell carcinoma of unknown primary tumor (MCC-UP)
patients … , as compared with tumors with Merkel cell carcinoma of known primary tumor (MCC-KP) …
patients … , as compared with tumors with Merkel cell carcinoma of known primary tumor (MCC-KP) …
[HTML][HTML] … analyses investigating disease biology and associations with outcomes in the JAVELIN Merkel 200 trial of avelumab in metastatic Merkel cell carcinoma
… Associations between biomarkers and response to immune checkpoint inhibitors in metastatic
Merkel cell carcinoma (mMCC) are not fully understood. We report exploratory biomarker …
Merkel cell carcinoma (mMCC) are not fully understood. We report exploratory biomarker …
[HTML][HTML] Evolving Applications of Circulating Tumor DNA in Merkel Cell Carcinoma
V Prakash, L Gao, SJ Park - Cancers, 2023 - mdpi.com
… burden which has potential prognostic and surveillance value as a tumor biomarker. Merkel
cell carcinoma (MCC) is a rare neuroendocrine skin cancer that requires close monitoring …
cell carcinoma (MCC) is a rare neuroendocrine skin cancer that requires close monitoring …
Virus-positive Merkel cell carcinoma is an independent prognostic group with distinct predictive biomarkers
… Merkel cell carcinoma (MCC) is an aggressive neuroendocrine … : Merkel cell polyomavirus
(MCPyV)-positive tumors expressing oncogenic viral T antigens, and MCPyV-negative tumors …
(MCPyV)-positive tumors expressing oncogenic viral T antigens, and MCPyV-negative tumors …
[HTML][HTML] Clinical, FDG-PET and molecular markers of immune checkpoint inhibitor response in patients with metastatic Merkel cell carcinoma
AM Weppler, A Pattison, P Bhave… - … of Cancer, 2020 - ncbi.nlm.nih.gov
… to compare treatment response by clinical and disease-specific biomarkers, including baseline
… A recent study that characterized the genomic landscape of 317 MCC tumors confirmed a …
… A recent study that characterized the genomic landscape of 317 MCC tumors confirmed a …
[HTML][HTML] Mutational landscape of virus-and uv-associated merkel cell carcinoma cell lines is comparable to tumor tissue
K Horny, P Gerhardt, A Hebel-Cherouny, C Wülbeck… - Cancers, 2021 - mdpi.com
… lines are frequently used as preclinical models to investigate biological function, we
considered it necessary to establish the genomic landscape of MCC cell lines by whole-exome …
considered it necessary to establish the genomic landscape of MCC cell lines by whole-exome …
[HTML][HTML] Merkel cell carcinoma
… The genomic landscape of MCC cell lines, which are used as preclinical models in functional
and pharmacological studies, has been analyzed by whole-exome sequencing. In keeping …
and pharmacological studies, has been analyzed by whole-exome sequencing. In keeping …
[HTML][HTML] Clinical and molecular characteristics associated with response to therapeutic PD-1/PD-L1 inhibition in advanced Merkel cell carcinoma
I Spassova, S Ugurel, L Kubat, L Zimmer… - … of cancer, 2022 - ncbi.nlm.nih.gov
… molecular biomarkers such as tumor PD-L1 expression or MCPyV status.2 5 6 Thus, with the
present study we aimed at testing clinically well applicable predictive biomarkers in a larger …
present study we aimed at testing clinically well applicable predictive biomarkers in a larger …