Single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer tumors
… genomic and transcriptomic data and new insights for the molecular mechanism studies of
colorectal cancer… tissues and primary and metastatic colorectal tumors for single-cell RNA-Seq…
colorectal cancer… tissues and primary and metastatic colorectal tumors for single-cell RNA-Seq…
Genomic landscapes and hallmarks of mutant RAS in human cancers
… % of colorectal carcinoma, 3.1 5.6 9.2 % of small bowel cancer, 1.3 3.8 8.4 % of ampullary
… distinct genomic landscapes To capture the genomic landscapes of RAS-mutant tumors, we …
… distinct genomic landscapes To capture the genomic landscapes of RAS-mutant tumors, we …
The expressed mutational landscape of microsatellite stable colorectal cancers
A Sveen, B Johannessen, IA Eilertsen, BI Røsok… - Genome Medicine, 2021 - Springer
… Colorectal cancer is the 2nd leading cause of cancer-related deaths with few patients
benefiting from biomarker-guided therapy. Mutation expression is essential for accurate …
benefiting from biomarker-guided therapy. Mutation expression is essential for accurate …
Whole genome sequencing of 2,023 colorectal cancers reveals mutational landscapes, new driver genes and immune interactions
…, J Mitchell, Genomics England Research Consortium… - bioRxiv, 2022 - biorxiv.org
… To characterise the somatic alterations in colorectal cancer (CRC), we conducted whole-genome
sequencing analysis of 2,023 tumours. We provide the most detailed high-resolution …
sequencing analysis of 2,023 tumours. We provide the most detailed high-resolution …
Comprehensive genomic profiling of colorectal cancer patients reveals differences in mutational landscapes among clinical and pathological subgroups
P Li, Q Meng, Y Xue, Z Teng, H Chen, J Zhang… - Frontiers in …, 2022 - frontiersin.org
… In our study, we performed genomic analysis on 133 patients with colorectal cancer. …
genomic analysis for 133 colorectal cancer patients using targeted sequencing with a 425 cancer…
genomic analysis for 133 colorectal cancer patients using targeted sequencing with a 425 cancer…
Colorectal cancer liver metastases: Genomics and biomarkers with focus on local therapies
Y Kitsel, T Cooke, V Sotirchos, CT Sofocleous - Cancers, 2023 - mdpi.com
… The purpose of this work is to review the utility of tumor genomics and molecular biomarkers
associated with colorectal cancer liver metastases (CRLM). As biomarkers have shown …
associated with colorectal cancer liver metastases (CRLM). As biomarkers have shown …
Genomic landscape of diploid and aneuploid microsatellite stable early onset colorectal cancer
Y Zhou, X Chen, J Chen, CD Kendrick… - Scientific reports, 2024 - nature.com
… Of significant interest was the comparison of somatic genomic landscapes in diploid and
aneuploid tumors and the presence of distinct mutational signatures arising in EOCRC that …
aneuploid tumors and the presence of distinct mutational signatures arising in EOCRC that …
[HTML][HTML] Whole genome sequencing of 2,023 colorectal cancers reveals mutational landscapes, new driver genes and immune interactions
… To characterise the somatic alterations in colorectal cancer (CRC), we conducted whole-genome
sequencing analysis of 2,023 tumours. We provide the most detailed high-resolution …
sequencing analysis of 2,023 tumours. We provide the most detailed high-resolution …
Stage-differentiated ensemble modeling of DNA methylation landscapes uncovers salient biomarkers and prognostic signatures in colorectal cancer progression
S Muthamilselvan, A Raghavendran, A Palaniappan - PloS one, 2022 - journals.plos.org
… In this study, we have developed a comprehensive computational framework for the stage-differentiated
modelling of DNA methylation landscapes in colorectal cancer (CRC). …
modelling of DNA methylation landscapes in colorectal cancer (CRC). …
Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
… dysfunction orchestrating the aberrant cancer transcriptional programs and transcriptional
dependencies. Here, we epigenetically characterize human colorectal cancer (CRC) using de …
dependencies. Here, we epigenetically characterize human colorectal cancer (CRC) using de …