SIX1 transcription factor: A review of cellular functions and regulatory dynamics
A Rafiq, S Aashaq, I Jan, MA Beigh - International Journal of Biological …, 2021 - Elsevier
… Aberrant expression of this homeoprotein has therefore been … , both SIX1 over-expressing
cells and the control cells get … SIX1 inhibits cellular senescence by regulating p16INK4A …
cells and the control cells get … SIX1 inhibits cellular senescence by regulating p16INK4A …
Dysfunction of programmed embryo senescence is linked to genetic developmental defects
C De Lope, R García-Lucena, M Magariños… - …, 2023 - journals.biologists.com
… that the SIX1 homeoprotein, an essential regulator of organogenesis, is also a repressor of
adult cellular senescence. … The homeoprotein SIX1 controls cellular senescence through the …
adult cellular senescence. … The homeoprotein SIX1 controls cellular senescence through the …
SINE OCULIS HOMEOBOX HOMOLOG 1 (SIX1) PLAYS A CRITICAL ROLE IN THE PROGRESSION OF PULMONARY FIBROSIS.
C Wilson - 2020 - digitalcommons.library.tmc.edu
… and cancer cell proliferation. Using IPF patient samples and healthy controls, Six1 and both
of … data that explores the role of cellular senescence in the context of Six1 in lung fibrosis. …
of … data that explores the role of cellular senescence in the context of Six1 in lung fibrosis. …
[HTML][HTML] Novel cellular senescence-related risk model identified as the prognostic biomarkers for lung squamous cell carcinoma
X Hu, L Guo, G Liu, Z Dai, L Wang, J Zhang… - Frontiers in …, 2022 - frontiersin.org
… SIX1 can also regulate cellular senescence by the regulation of p16INK4A and
differentiation-related genes (47). … In this study, senescence-related genes were found to control …
differentiation-related genes (47). … In this study, senescence-related genes were found to control …
[HTML][HTML] Transcriptional regulation of CDKN2A/p16 by sirtuin 7 in senescence
S Rodríguez, LG Bermúdez… - Molecular …, 2022 - spandidos-publications.com
… p16INK4A mediates senescence via the retinoblastoma … /p16 transcriptional control during
replicative senescence in … participated in cell senescence via transcriptional regulation of …
replicative senescence in … participated in cell senescence via transcriptional regulation of …
Six1 as a Tumor Suppressor Candidate in Diffuse Intrinsic Pontine Glioma
A Racanelli - 2024 - search.proquest.com
… Using the replication-competent avian sarcoma-leukosis … with Six1 overexpression to isogenic
controls with an otherwise identical genetic composition. In our studies, we found that Six1 …
controls with an otherwise identical genetic composition. In our studies, we found that Six1 …
SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells
RJ Bevacqua, JY Lam, H Peiris… - Genes & …, 2021 - genesdev.cshlp.org
… Using genetic approaches, we show that SIX2 is required for expression of multiple hallmark
genes in human β cells. In addition to regulation of genes governing β-cell … control β-cell …
genes in human β cells. In addition to regulation of genes governing β-cell … control β-cell …
Myogenesis control by SIX transcriptional complexes
P Maire, M Dos Santos, R Madani, I Sakakibara… - Seminars in cell & …, 2020 - Elsevier
… SIX1 in human fibroblasts represses senescence and stemness through the control of p16INK4a
… to the direct involvement of these two homeoproteins in the control of early epaxial Myf5 …
… to the direct involvement of these two homeoproteins in the control of early epaxial Myf5 …
Long non-coding RNA (LncRNA) CASC9/microRNA (miR)-590–3p/sine oculis homeobox 1 (SIX1)/NF-κB axis promotes proliferation and migration in breast cancer
J Chang, Y Zhang, X Ye, H Guo, K Lu, Q Liu… - …, 2021 - Taylor & Francis
… 1 (SIX1) gene were determined through qRT-PCR. We conducted cell counting kit-8 (CCK-8)
assays to assess cell … to detect cell migration/invasion, and flow cytometry to evaluate cell …
assays to assess cell … to detect cell migration/invasion, and flow cytometry to evaluate cell …
The signaling axis CDK12-BRCA1 mediates dinaciclib associated radiosensitivity through p53-mediated cellular senescence.
N Garcia-Flores, DM Fernandez-Aroca… - bioRxiv, 2024 - biorxiv.org
The signalling axis CDK12-BRCA1 mediates dinaciclib associated radiosensitivity through
p53-mediated cellular senescence. Natali Page 1 1 The signalling axis CDK12-BRCA1 …
p53-mediated cellular senescence. Natali Page 1 1 The signalling axis CDK12-BRCA1 …