Histamine Receptors: Ex Vivo Functional Studies Enabling the Discovery of Hits and Pathways
A Seldeslachts, S Peigneur, J Tytgat - Membranes, 2023 - mdpi.com
… GIRK channels are members of a family of inwardly rectifying … of histamine receptors in
Xenopus Laevis oocytes, human H1… to couple with the inward rectifier potassium channels GIRK1/…
Xenopus Laevis oocytes, human H1… to couple with the inward rectifier potassium channels GIRK1/…
Histamine H3 Receptor Activation Modulates Glutamate Release in the Corticostriatal Synapse by Acting at CaV2.1 (P/Q-Type) Calcium Channels and GIRK (KIR3) …
H Vázquez-Vázquez, C Gonzalez-Sandoval… - Cellular and Molecular …, 2022 - Springer
Histamine H3 Receptor Activation Modulates Glutamate … IR 3 channels has been shown
in Xenopus oocytes upon the … of the GIRK channels present in the corticostriatal terminals. …
in Xenopus oocytes upon the … of the GIRK channels present in the corticostriatal terminals. …
[HTML][HTML] Ligand-directed biased agonism at human histamine H3 receptor isoforms across Gαi/o-and β-arrestin2-mediated pathways
SN Rahman, F Imhaouran, R Leurs… - Biochemical …, 2023 - Elsevier
… The human histamine H 3 receptor (hH 3 R) is a neurotransmitter receptor in the central
nervous system (CNS) [1] that has been a longstanding drug target for various CNS disorders, …
nervous system (CNS) [1] that has been a longstanding drug target for various CNS disorders, …
[HTML][HTML] Voltage-dependent dopamine potency at D1-like dopamine receptors
R Ågren, K Sahlholm - Frontiers in Pharmacology, 2020 - frontiersin.org
… -clamp in Xenopus oocytes heterologously expressing GPCRs … response in oocytes expressing
GIRK channels without D 1 … R has previously been reported to couple to PTX-sensitive G …
GIRK channels without D 1 … R has previously been reported to couple to PTX-sensitive G …
[PDF][PDF] VU Research Portal
TAM Mocking - Angew. Chem. Int. Ed - research.vu.nl
… We developed a set of sixteen photoswitchable ligands for the human histamine H3 receptor
(… The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes. Eur. J. …
(… The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes. Eur. J. …
A Review on Current Research On H3 And H4 Receptors
V Chaurasiya, V Bhoir, S Bhundere… - Asian Journal of …, 2023 - ajprd.com
… receptors has been shown both in vitro (human, pig, guinea-pig, rabbit, rat isolated tissues)
and in vivo (rat, guinea-pig)[21].Histamine H3 receptors … [25-26]Histamine H3 receptor can …
and in vivo (rat, guinea-pig)[21].Histamine H3 receptors … [25-26]Histamine H3 receptor can …
Illuminating histamine receptor photopharmacology: From design and synthesis to in vivo proof of principle
NJ Hauwert - 2022 - research.vu.nl
… the GPCR of interest and a GIRK channel are coexpressed, … flow of ions through GIRK channels
which open and close … a prototypic family A GPCR, the histamine H3 receptor (H3R). The …
which open and close … a prototypic family A GPCR, the histamine H3 receptor (H3R). The …
Electrophysiology-Based Investigations of G Protein-Coupled Receptor Pharmacology
R Ågren - 2020 - search.proquest.com
… In the thesis, M2R, D2R and D3R were investigated using two-electrode voltage-clamp in
Xenopus laevis oocytes co-expressing the respective receptor and GIRK channels. M2R …
Xenopus laevis oocytes co-expressing the respective receptor and GIRK channels. M2R …
[HTML][HTML] Neurohumoral control of sinoatrial node activity and heart rate: insight from experimental models and findings from humans
… oocytes. One suggestion is that GIRK channels are intrinsically inhibited by a terminal domain
… of one of these receptors (BK 2 R) and HCN1 or HCN2 in Xenopus oocytes, a modulatory …
… of one of these receptors (BK 2 R) and HCN1 or HCN2 in Xenopus oocytes, a modulatory …
Membrane Heteroreceptor Complexes as Second-Order Protein Modulators: A Novel Integrative Mechanism through Allosteric Receptor–Receptor Interactions
M Mirchandani-Duque, M Choucri… - Membranes, 2024 - mdpi.com
… couples to G-protein [37,38]. Similar trans-activation mechanisms have been observed in the
luteinizing hormone (LH) receptor, a Family A receptor, … receptor from the GIRK channels in …
luteinizing hormone (LH) receptor, a Family A receptor, … receptor from the GIRK channels in …