Role of viral protein U (Vpu) in HIV-1 infection and pathogenesis

N Khan, JD Geiger - Viruses, 2021 - mdpi.com
Human immunodeficiency virus (HIV)-1 and HIV-2 originated from cross-species … , CD4
proteins levels, and immune evasion. This review will focus of critical aspects of Vpu including its …

Detection of the HIV-1 Accessory Proteins Nef and Vpu by Flow Cytometry Represents a New Tool to Study Their Functional Interplay within a Single Infected CD4+ T …

J Prévost, J Richard, R Gasser, H Medjahed… - Journal of …, 2022 - Am Soc Microbiol
… The human immunodeficiency virus type 1 (HIV-1) genome … of these proteins together with
host and viral proteins within a … Nef and Vpu expression predicts the susceptibility of HIV-1-…

The HIV-1 accessory protein Vpu downregulates peroxisome biogenesis

Z Xu, R Lodge, C Power, EA Cohen, TC Hobman - MBio, 2020 - Am Soc Microbiol
Viruses have evolved intricate strategies to interfere with and/or … Human immunodeficiency
virus type 1 (HIV-1) causes … As a first step in determining which HIV protein(s) was …

[PDF][PDF] Human immunodeficiency virus type 1: Role of proteins in the context of viral life cycle

V Jha, K Rustagi, K Gharat, N Sonawane… - J Adv Biotechnol Exp …, 2022 - researchgate.net
… potent antihuman immunodeficiency virus type 1 (HIV-1) activity … that blocks HIV-1 entry into
host cells by interfering with virus-… The Vpu protein: new concepts in virus release and CD4 …

Differential dysregulation of β-TrCP1 and-2 by HIV-1 Vpu leads to inhibition of canonical and non-canonical NF-κB pathways in infected cells

S Pickering, J Sumner, C Kerridge, M Perera, S Neil - Mbio, 2023 - Am Soc Microbiol
… The HIV-1 Vpu protein is expressed late in the virus lifecycle to promote infectious virus
To demonstrate that Vpu specifically affects processing of p105 to p50, rather than acting …

Insights into the oligomeric structure of the HIV-1 Vpu protein

S Majeed, O Adetuyi, PP Borbat, MM Islam… - Journal of structural …, 2023 - Elsevier
… and provide insights into how the Vpu environment affects the oligomer formation. For these
… of the viral protein U (Vpu) protein encoded by the human immunodeficiency virus 1 (HIV-1). …

Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1

M Volcic, KMJ Sparrer, L Koepke, D Hotter… - Nature …, 2020 - nature.com
… consequences of human immunodeficiency virus type 1 (HIV-1) … how HIV-1 avoids immune
sensing and affects DNA repair … proviral HIV-1 DNA, which bypasses the earliest steps of viral

… Adaptive Mutation of HIV-1 Degrades Tetherin in Northern Pig-Tailed Macaques (Macaca leonina) Mainly via the Ubiquitin-Proteasome Pathway and Increases Viral …

Y Lu, W Pang, MD Zhang, JH Song, F Shen… - Journal of …, 2023 - Am Soc Microbiol
human immunodeficiency virus type 1 (HIV-1) precursor, its … about how it affects the degradation
of mTetherin by Vpu G53D . … This is a key step forward in overcoming the barrier of cross-…

[PDF][PDF] THE MECHANISM OF HIV-1 SENSING IN CD4+ T CELLS: THE ROLE OF NEWLY EXPRESSED VPR AND VPU

N Elhemdaoui - 2020 - libstore.ugent.be
Human Immunodeficiency Virus type 1 (HIV-1) is the … hypothesize that both viral proteins
might interfere with factors in … with the one-step SG-PERT assay as described earlier by our …

[图书][B] Tat-Vpu Peptide Inducing a Shock Effect on Human Immunodeficiency Virus Type-1 Infected Primary Macrophage Cells and Understanding a Novel NLRP3 …

J Hanna - 2020 - search.proquest.com
… We show that Tat-Vpu is able to increase HIV-1 viral release in infected macrophages
through the LVEM66 amino acid … HIV-1 infects CD4+ cells through a series of steps. Initially …