T lymphocyte exhaustion during human and experimental visceral leishmaniasis

JC Costa-Madeira, GB Trindade, PHP Almeida… - … in Immunology, 2022 - frontiersin.org
A key point of immunity against protozoan Leishmania parasites is the development of an
optimal T cell response, which includes a low apoptotic rate, high proliferative activity and …

Role of cytokines in experimental and human visceral leishmaniasis

M Samant, U Sahu, SC Pandey… - Frontiers in cellular and …, 2021 - frontiersin.org
… injection of visceral Leishmania results in a self-healing chronic infection. In addition,
cytokine phenotypes exhibited in the mouse model by viscerotropic Leishmania are not …

Hepatomegaly associated with non-obstructive sinusoidal dilation in experimental visceral leishmaniasis

K Maeda, S Sadoughi, A Morimoto, K Uchida… - Pathogens, 2021 - mdpi.com
… of the genus Leishmania. … immunopathology of the symptom has not been well investigated.
Using our chronic model of experimental VL, we examined the influence of Leishmania

Phenotypical characterization of spleen remodeling in murine experimental visceral leishmaniasis

CVB Melo, MDER Hermida, BR Mesquita… - … in immunology, 2020 - frontiersin.org
Background: Visceral leishmaniasis (VL) is caused by Leishmania infantum or L. donovani
infection. One of the main problems related to this disease is the emergence of severe clinical …

Immunomodulatory role of Th17 pathway in experimental visceral leishmaniasis

R Khatonier, G Ahmed, P Sarmah, K Narain, AM Khan - Immunobiology, 2021 - Elsevier
… is poorly understood in visceral leishmaniasis. Therefore, we investigated the role of the
Th17 pathway in experimental VL during active Leishmania donovani infection and treatment …

A specific Leishmania infantum polyepitope vaccine triggers Th1-type immune response and protects against experimental visceral leishmaniasis

TLVDP Ostolin, MR Gusmão, FAS Mathias… - … Immunology, 2022 - Elsevier
… a polyepitope T-cell antigen candidate against visceral leishmaniasis in a murine model.
BALB/c … Our candidate was considered potential against visceral leishmaniasis, and eventually, …

Review on the role of host immune response in protection and immunopathogenesis during cutaneous leishmaniasis infection

T Dubie, Y Mohammed - Journal of immunology research, 2020 - Wiley Online Library
… Generally, a high antibody level is a marker of progressive disease in visceral leishmaniasis
[51], whereas the role of antibody titers in resolution of CL and protective immunity is largely …

Understanding the immune responses involved in mediating protection or immunopathology during leishmaniasis

T Pacheco-Fernandez, G Volpedo… - Biochemical Society …, 2021 - portlandpress.com
… , such as cutaneous (CL), diffuse cutaneous (DCL), mucosal (MCL) and visceral leishmaniasis
(VL)… immune responses play critical roles in the defense against leishmaniasis. However, …

Increased levels of cortisol are associated with the severity of experimental visceral leishmaniasis in a Leishmania (L.) infantum-hamster model

TD Barros-Gonçalves, AF Saavedra… - PLoS Neglected …, 2021 - journals.plos.org
… We conducted this study in golden hamsters, a suitable model for human visceral
leishmaniasis (VL), to investigate the relationship of Leishmania (L.) infantum infection on cortisol …

Leishmaniasis immunopathology—impact on design and use of vaccines, diagnostics and drugs

PM Kaye, I Cruz, A Picado, K Van Bocxlaer… - … in immunopathology, 2020 - Springer
… forms, visceral leishmaniasis (VL) and cutaneous or … Leishmaniasis is a disease complex
with two main clinical presentations—visceral leishmaniasis (VL, or kala-azar) and cutaneous