T lymphocyte exhaustion during human and experimental visceral leishmaniasis
JC Costa-Madeira, GB Trindade, PHP Almeida… - … in Immunology, 2022 - frontiersin.org
A key point of immunity against protozoan Leishmania parasites is the development of an
optimal T cell response, which includes a low apoptotic rate, high proliferative activity and …
optimal T cell response, which includes a low apoptotic rate, high proliferative activity and …
Role of cytokines in experimental and human visceral leishmaniasis
… injection of visceral Leishmania results in a self-healing chronic infection. In addition,
cytokine phenotypes exhibited in the mouse model by viscerotropic Leishmania are not …
cytokine phenotypes exhibited in the mouse model by viscerotropic Leishmania are not …
Hepatomegaly associated with non-obstructive sinusoidal dilation in experimental visceral leishmaniasis
K Maeda, S Sadoughi, A Morimoto, K Uchida… - Pathogens, 2021 - mdpi.com
… of the genus Leishmania. … immunopathology of the symptom has not been well investigated.
Using our chronic model of experimental VL, we examined the influence of Leishmania …
Using our chronic model of experimental VL, we examined the influence of Leishmania …
Phenotypical characterization of spleen remodeling in murine experimental visceral leishmaniasis
CVB Melo, MDER Hermida, BR Mesquita… - … in immunology, 2020 - frontiersin.org
Background: Visceral leishmaniasis (VL) is caused by Leishmania infantum or L. donovani
infection. One of the main problems related to this disease is the emergence of severe clinical …
infection. One of the main problems related to this disease is the emergence of severe clinical …
Immunomodulatory role of Th17 pathway in experimental visceral leishmaniasis
… is poorly understood in visceral leishmaniasis. Therefore, we investigated the role of the
Th17 pathway in experimental VL during active Leishmania donovani infection and treatment …
Th17 pathway in experimental VL during active Leishmania donovani infection and treatment …
A specific Leishmania infantum polyepitope vaccine triggers Th1-type immune response and protects against experimental visceral leishmaniasis
TLVDP Ostolin, MR Gusmão, FAS Mathias… - … Immunology, 2022 - Elsevier
… a polyepitope T-cell antigen candidate against visceral leishmaniasis in a murine model.
BALB/c … Our candidate was considered potential against visceral leishmaniasis, and eventually, …
BALB/c … Our candidate was considered potential against visceral leishmaniasis, and eventually, …
Review on the role of host immune response in protection and immunopathogenesis during cutaneous leishmaniasis infection
T Dubie, Y Mohammed - Journal of immunology research, 2020 - Wiley Online Library
… Generally, a high antibody level is a marker of progressive disease in visceral leishmaniasis
[51], whereas the role of antibody titers in resolution of CL and protective immunity is largely …
[51], whereas the role of antibody titers in resolution of CL and protective immunity is largely …
Understanding the immune responses involved in mediating protection or immunopathology during leishmaniasis
T Pacheco-Fernandez, G Volpedo… - Biochemical Society …, 2021 - portlandpress.com
… , such as cutaneous (CL), diffuse cutaneous (DCL), mucosal (MCL) and visceral leishmaniasis
(VL)… immune responses play critical roles in the defense against leishmaniasis. However, …
(VL)… immune responses play critical roles in the defense against leishmaniasis. However, …
Increased levels of cortisol are associated with the severity of experimental visceral leishmaniasis in a Leishmania (L.) infantum-hamster model
TD Barros-Gonçalves, AF Saavedra… - PLoS Neglected …, 2021 - journals.plos.org
… We conducted this study in golden hamsters, a suitable model for human visceral
leishmaniasis (VL), to investigate the relationship of Leishmania (L.) infantum infection on cortisol …
leishmaniasis (VL), to investigate the relationship of Leishmania (L.) infantum infection on cortisol …
Leishmaniasis immunopathology—impact on design and use of vaccines, diagnostics and drugs
… forms, visceral leishmaniasis (VL) and cutaneous or … Leishmaniasis is a disease complex
with two main clinical presentations—visceral leishmaniasis (VL, or kala-azar) and cutaneous …
with two main clinical presentations—visceral leishmaniasis (VL, or kala-azar) and cutaneous …
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