… located in hypoxic regions of mouse PDAC in vivo and that the hypoxia-related gene …
cocultures of pancreatic cancer cells and fibroblasts, we demonstrate that hypoxia promotes …

… of the early steps of the metastatic cascade in pancreatic cancer. Specifically, we will …
requirement for metastasis, summarize our understanding of how PDAC cells invade and degrade …

… on the metastatic process. In this … pancreatic cancer cells through their metastatic journey.
Our focus is on biology that instructs cancer cell dissemination away from the primary tumor …

… Furthermore, HIF-1α was found to mediate hedgehog signaling for EMT and invasion in
pancreatic cancer cells and the silencing of HIF-1α would reverse hypoxia-induced hedgehog …

… to tumor, nodes and metastasis stage and distant metastasis. … signaling pathway, and
cancer metastasis through SOCS5 … mechanisms of pancreatic cancer invasion and metastasis. …

… that pancreatic cancer cells maintain growth and oxidative metabolism during conditions of
severe hypoxia; … are uniquely sustained in pancreatic cancer cells exposed to extremely low …

… This outcome reminds us that the cancer stroma might not … well that limits cancer cells from
further migration and invasion. … the TME of pancreatic cancer, keep the tumor stroma structure …

… pancreatic cancer cell migration, invasion, and EMT after contact-independent co-culture with
pancreatic cancer … and IL8 under hypoxia 18 , all of which have been reported to promote …

… Furthermore, enhancement in the aggressiveness of cancer cells has been related to the
development of drug resistance. Metastasis of pancreatic cancer (PC) cells has been …

… hypoxia-induced tumorigenesis in pancreatic cancer. The results revealed that miR-519
suppressed the invasion, and induced the apoptosis, of pancreatic cancer … of pancreatic cancer …