Physiological and pathological roles of protein kinase A in the heart
… PKA-R subunits to induce dissociation of the tetrameric PKA … C phosphorylation is also a key
regulator of cardiac inotropy. … the synthetic catecholamine isoproterenol in rats induces PKA-…
regulator of cardiac inotropy. … the synthetic catecholamine isoproterenol in rats induces PKA-…
[HTML][HTML] Status of β1-adrenoceptor signal transduction system in cardiac hypertrophy and heart failure
NS Dhalla, SK Bhullar, A Adameova… - Reviews in …, 2023 - imrpress.com
… catecholamines for a short duration augments cardiac … and inotropic responses as well
as cardiac hypertrophy whereas … in dissociation constant (K d value) or isoproterenol-induced …
as cardiac hypertrophy whereas … in dissociation constant (K d value) or isoproterenol-induced …
Adrenergic downregulation in critical care: molecular mechanisms and therapeutic evidence
A Belletti, G Landoni, VV Lomivorotov, A Oriani… - Journal of cardiothoracic …, 2020 - Elsevier
… Dissociation of G protein leads to activation of adenylyl cyclase… the adrenergic and inotropic
reserve of the heart, which has … development of catecholamine-induced cardiomyopathy and …
reserve of the heart, which has … development of catecholamine-induced cardiomyopathy and …
Paroxetine attenuates cardiac hypertrophy via blocking GRK2 and ADRB1 interaction in hypertension
X Sun, M Zhou, G Wen, Y Huang, J Wu… - … of the American Heart …, 2021 - Am Heart Assoc
… values can be used to determine an equilibrium dissociation … that cardiac GRK2 is a major
factor regulating inotropic and … With Gαq promoting cardiac hypertrophy and catecholamines …
factor regulating inotropic and … With Gαq promoting cardiac hypertrophy and catecholamines …
Catecholamines and blood pressure regulation
CJ Fernandez, FWF Hanna, K Pacak, MA Nazari - Endocrine Hypertension, 2023 - Elsevier
… , catecholamines increase inotropy by … to catecholamine-induced cardiac hypertrophy,
which in the initial compensated stage is associated with preserved or even enhanced ventricular …
which in the initial compensated stage is associated with preserved or even enhanced ventricular …
Chronic isoprenaline/phenylephrine vs. exclusive isoprenaline stimulation in mice: critical contribution of alpha1-adrenoceptors to early cardiac stress responses
M Dewenter, J Pan, L Knödler, N Tzschöckel… - … research in cardiology, 2022 - Springer
… 6 days of chronic catecholamine perfusion at basal conditions … For enzymatic dissociation,
the heart was perfused with … -AR activity on cardiac inotropy and adrenergic desensitization …
the heart was perfused with … -AR activity on cardiac inotropy and adrenergic desensitization …
Androgen effects on the adrenergic system of the vascular, airway, and cardiac myocytes and their relevance in pathological processes
A Carbajal-García, J Reyes-García… - International Journal of …, 2020 - Wiley Online Library
… and epinephrine can induce positive inotropic and … , dissociation of chaperone proteins, and
binding to its cytosolic receptor. … Physiologically, catecholamines, through β-ARs, induce the …
binding to its cytosolic receptor. … Physiologically, catecholamines, through β-ARs, induce the …
… Syndrome Study Group and Myocardial Function Working Group of the E uropean Society of Cardiology–Part 1: overview and the central role for catecholamines and …
… -induced negative inotropic responses in isolated ventricular … towards cardiac remodelling
consisting of cardiac hypertrophy, … of cardiac remodelling were shown to be dissociated from …
consisting of cardiac hypertrophy, … of cardiac remodelling were shown to be dissociated from …
Current Developments on the Role of α1-Adrenergic Receptors in Cognition, Cardioprotection, and Metabolism
DM Perez - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
… similar affinity to the catecholamines, they can regulate different … stimulation can regulate a
positive inotropic response in the heart, … Cardiac hypertrophy can be a normal physiological …
positive inotropic response in the heart, … Cardiac hypertrophy can be a normal physiological …
Harmine is an effective therapeutic small molecule for the treatment of cardiac hypertrophy
J Huang, Y Liu, J Chen, X Lu, W Zhu, L Qin… - Acta Pharmacologica …, 2022 - nature.com
… Cardiomyocytes at day 30 of differentiation were dissociated into single … NE is a catecholamine
that can induce hypertrophy of … that harmine inhibited the positive inotropic effect of NE on …
that can induce hypertrophy of … that harmine inhibited the positive inotropic effect of NE on …