Apolipoprotein E and atherosclerosis

AD Marais - Current atherosclerosis reports, 2021 - Springer
Purpose of Review The functions, genetic variations and impact of apolipoprotein E on
lipoprotein metabolism in general are placed in the context of clinical practice dealing with …

[HTML][HTML] Apolipoprotein E and Alzheimer's disease

BR Troutwine, L Hamid, CR Lysaker, TA Strope… - … Pharmaceutica Sinica B, 2022 - Elsevier
APOE does play a role in atherosclerosis as ApoE knockout mice have severe … suggest
APOE does not play a critical role in astrocyte Aβ clearance but LRP1 does. This suggests APOE

Apolipoproteins in vascular biology and atherosclerotic disease

A Mehta, MD Shapiro - Nature Reviews Cardiology, 2022 - nature.com
Apolipoproteins have many important roles in normal human vascular biology. Insoluble …
-CIII inhibits TRL remnant uptake in the liver by displacing apolipoprotein E (ApoE) from the …

Selenium nanoparticles inhibit the formation of atherosclerosis in apolipoprotein E deficient mice by alleviating hyperlipidemia and oxidative stress

S Xiao, L Mao, J Xiao, Y Wu, H Liu - European journal of pharmacology, 2021 - Elsevier
… Thus, this study aimed at explore the anti-atherosclerotic … (CS-SeNPs), in apolipoprotein E
deficient (ApoE - /- ) mice fed with … /day) could reduce atherosclerotic lesions in ApoE - /- mice …

Apolipoprotein E and Alzheimer's disease: findings, hypotheses, and potential mechanisms

N Koutsodendris, MR Nelson, A Rao… - Annual Review of …, 2022 - annualreviews.org
… Recent discoveries are further expanding our understanding of how apoE contributes to
neuronal maintenance. Excitingly, apoE has been found to play a critical role in the …

[PDF][PDF] Apolipoprotein E: structural insights and links to Alzheimer disease pathogenesis

Y Chen, MR Strickland, A Soranno, DM Holtzman - Neuron, 2021 - cell.com
… In addition to the critical role that ApoE plays in peripheral cholesterol metabolism, ApoE
was found to be the primary apolipoprotein lipid and cholesterol transporter in the …

Apolipoprotein E in cardiometabolic and neurological health and diseases

J Alagarsamy, A Jaeschke, DY Hui - International Journal of Molecular …, 2022 - mdpi.com
… of apolipoprotein E (apoE) deficiency and polymorphisms with pathogenesis of numerous
chronic diseases, including atherosclerosis, … diseases, apoE also plays an important role in …

Quercetin inhibited endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice: critical roles for NADPH oxidase and heme oxygenase-1

M Luo, R Tian, N Lu - Journal of Agricultural and Food Chemistry, 2020 - ACS Publications
… and oxidative stress play important roles in endothelial dysfunction and atherosclerosis.
Herein, … Our results demonstrated the critical roles of NADPH oxidase and HO-1 for the indirect …

Therapeutic approaches targeting Apolipoprotein E function in Alzheimer's disease

T Williams, DR Borchelt, P Chakrabarty - Molecular neurodegeneration, 2020 - Springer
… lipid metabolism, APOE has a key role in controlling … The Apoe deficient mice, Apoe
hypomorphic mice and APOE knock-in mice have been key resources in the field of atherosclerosis

Butyrate protects against high‐fat diet‐induced atherosclerosis via up‐regulating ABCA1 expression in apolipoprotein E‐deficiency mice

Y Du, X Li, C Su, M Xi, X Zhang, Z Jiang… - British Journal of …, 2020 - Wiley Online Library
… In conclusion, our findings suggest that butyrate plays a multi-faceted role in its athero-protective
effect, at least an important part of which is mediated by modulation of lipid metabolism, …