Atherosclerosis: Known and unknown

J Fan, T Watanabe - Pathology international, 2022 - Wiley Online Library
… to be involved in the pathogenesis of atherosclerosis. As such, macrophages play a central
role in the initiation and progression of atherosclerosis. Macrophages are diverse in their …

Lipoprotein receptor signalling in atherosclerosis

C Mineo - Cardiovascular research, 2020 - academic.oup.com
… lipoprotein receptor, and apolipoprotein E receptor 2. The … receptors influence atherosclerosis
progression through a … that also play key roles in atherosclerosis and cardiovascular …

The anti-atherosclerosis effect of anakinra, a recombinant human interleukin-1 receptor antagonist, in apolipoprotein E knockout mice

EJ Ku, BR Kim, JI Lee, YK Lee, TJ Oh, HC Jang… - International Journal of …, 2022 - mdpi.com
… inflammation plays a critical role in the process of atherosclerosis [2]. Beyond the roles of
lipid-… of chronic inflammation may be an important component of anti-atherosclerosis treatment. …

Amygdalin attenuates atherosclerosis and plays an anti-inflammatory role in ApoE knock-out mice and bone marrow-derived macrophages

Y Wang, Q Jia, Y Zhang, J Wei, P Liu - Frontiers in Pharmacology, 2020 - frontiersin.org
… influence of amygdalin on high-fat diet-induced atherosclerosis in ApoE knock-out (ApoE
−/− ) mice, and unravel its anti-inflammatory mechanism. ApoE −/− mice fed with high-fat diet …

Cholesterol, atherosclerosis, and APOE in vascular contributions to cognitive impairment and dementia (VCID): potential mechanisms and therapy

MT Duong, IM Nasrallah, DA Wolk… - Frontiers in Aging …, 2021 - frontiersin.org
Apolipoprotein E (APOE) is a cholesterol and … in atherosclerosis may be analogous to the
aging, cholesterol-rich, lipid-laden glia in the brain; APOE and TREM2 may play key roles in …

(−)-Epicatechin gallate blocks the development of atherosclerosis by regulating oxidative stress in vivo and in vitro

J Yu, W Li, X Xiao, Q Huang, J Yu, Y Yang, T Han… - Food & Function, 2021 - pubs.rsc.org
… SOD is an important antioxidant enzyme in the body. … atherosclerotic plaques and accelerates
inflammation, which is closely related to the onset of CVD. ICAM-1 plays an important role

Acacetin exerts antioxidant potential against atherosclerosis through Nrf2 pathway in apoE−/− Mice

Y Wu, F Song, Y Li, J Li, Y Cui, Y Hong… - Journal of cellular …, 2021 - Wiley Online Library
… flavonoid could attenuate atherosclerosis in apolipoprotein E deficiency (apoE −/… central
role of statins in management, anti-oxidation is a topic of considerable interest in atherosclerosis

Interactions between apolipoprotein E metabolism and retinal inflammation in age-related macular degeneration

ML Hu, J Quinn, K Xue - Life, 2021 - mdpi.com
… but also Alzheimer’s disease (AD) and atherosclerosis [26,27,28]. Two single … key constituent
of drusen, the function of APOE as a cholesterol and lipid transporter likely plays a key role

Endothelial dysfunction in small arteries and early signs of atherosclerosis in ApoE knockout rats

S Berenji Ardestani, I Eftedal, M Pedersen… - Scientific reports, 2020 - nature.com
Apolipoprotein knockout (ApoE KO) mice have been widely used to study atherosclerosis
pathology and treatment 15 . ApoE plays an important role in cholesterol transport and …

Lipoprotein (a) in atherosclerosis: from pathophysiology to clinical relevance and treatment options

A Rehberger Likozar, M Zavrtanik… - Annals of medicine, 2020 - Taylor & Francis
… -inflammatory roles. Here, we review recent data on the role of Lp(a) in the atherosclerotic
process… population, and further supports the important role of Lp(a) levels in the progression of …