… In conclusion, current evidence supports that dysfunctional HDL, rather than HDL level,
plays a more significant role in atherosclerosis. Further studies on the causality of the possible …

… Dysregulation of lipid metabolism has emerged as a central component of many
neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E (APOE), …

… mtDNA mutations have an important role in atherosclerosis. These mutations lead to impaired
glucose and fat metabolism, increased oxidative stress, ROS generation, and cell death (…

… Although apoE has been classically associated with lipoprotein metabolism and atherosclerosis,
it … Notably, apoE exists in three isoforms (apoE2, apoE3 and apoE4) giving rise to three …

… by receptor-mediated mechanisms involving apolipoprotein E. Circulating triglyceride-rich …
All are pro-atherogenic and play key roles in the transport of cholesterol and triglycerides in …

… that HDAC-dependent pathways play an important role in mediating Nox up-regulation, …
Together, the data of present study extend to experimental atherosclerosis the role of HDAC …

… of apoE (apolipoprotein E) encoded by the APOE gene is to transport cholesterol and other
lipids in the brain, apoE … Our results collectively support a critical role of brain pericytes in …

… a prominent role in the onset of notorious atherosclerosis, a disease of medium to large
arteries. Atherosclerosis … lipoproteins (HDLs), endogenous apolipoprotein E (ApoE), and ApoA-I …

… Oxidative stress plays an important role in atherosclerotic … Apolipoprotein E knock-out (apoE
-/- ) mice that are also … are characterized by accelerated atherosclerosis development in the …

… We have previously shown that apolipoprotein E-knockout (ApoE −/− ) mice lacking Dgat1
… beneficial effects on atherosclerosis. Due to our recent results on the critical role of intestinal …