[HTML][HTML] Combination of tanshinone IIA and astragaloside IV attenuate atherosclerotic plaque vulnerability in ApoE (-/-) mice by activating PI3K/AKT signaling and …

N Wang, X Zhang, Z Ma, J Niu, S Ma, W Wenjie… - Biomedicine & …, 2020 - Elsevier
… in atherosclerosis. However, the combined effect of these two drugs on atherosclerotic plaque
… In the current study, we evaluate the effects of TS IIA and AS IV on atherosclerotic unstable …

[HTML][HTML] The multifaceted impact of complement on atherosclerosis

MG Kiss, CJ Binder - Atherosclerosis, 2022 - Elsevier
… complement component C3 appears to have a crucial role in tempering lesion progression
by aiding the clearance of apoptotic cells, cascade propagation to the terminal pathway …

Apolipoprotein E promotes immune suppression in pancreatic cancer through NF-κB–mediated production of CXCL1

SB Kemp, ES Carpenter, NG Steele, KL Donahue… - Cancer research, 2021 - AACR
Apolipoprotein E (ApoE) is secreted at high levels by … in diseases such as Alzheimer's disease
and atherosclerosis (6). Increased … knockdown of LDLR suggests it plays a prominent role. …

APOE gene variants in primary dyslipidemia

Y Abou Khalil, JP Rabès, C Boileau, M Varret - Atherosclerosis, 2021 - Elsevier
Apolipoprotein E (apoE) is a major apolipoprotein involved in lipoprotein metabolism. It is
a … of apoE in a portion of VLDL, HDL, and LDL respectively [4]. ApoE plays a key role in …

Multifaceted roles of APOE in Alzheimer disease

RJ Jackson, BT Hyman, A Serrano-Pozo - Nature Reviews Neurology, 2024 - nature.com
… ), our understanding of the link between the apolipoprotein E (APOE) gene and AD risk has
… Neither allele is associated with atherosclerosis in the circle of Willis or microinfarcts 55 . …

Inflammation and atherosclerosis: what is on the horizon?

N Ruparelia, R Choudhury - Heart, 2020 - heart.bmj.com
… Cytokines also play critical roles in the pathogenesis of atherosclerosis and are produced by,
and … . Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E

Amorphous silica nanoparticles accelerated atherosclerotic lesion progression in ApoE−/− mice through endoplasmic reticulum stress-mediated CD36 up-regulation …

R Ma, Y Qi, X Zhao, X Li, X Sun, P Niu, Y Li… - Particle and Fibre …, 2020 - Springer
… and progression of atherosclerotic plaque, especially plays a crucial role in the regulation
of … effect of SiNPs on the progression of atherosclerotic plaque in ApoE −/− mice model, a …

Both gut microbiota and cytokines act to atherosclerosis in ApoE−/− mice

Q Liu, Y Li, X Song, J Wang, Z He, J Zhu, H Chen… - Microbial …, 2020 - Elsevier
… reduced the size of atherosclerotic plaques in ApoE−/− mice. … precise role of Akkermansia
muciniphila in atherosclerosis. … plays important roles in the development of atherosclerosis. …

Empagliflozin ameliorates endothelial dysfunction and suppresses atherogenesis in diabetic apolipoprotein E-deficient mice

B Ganbaatar, D Fukuda, M Shinohara, S Yagi… - European Journal of …, 2020 - Elsevier
… plays a critical role in the … of atherosclerosis, we performed en face Sudan IV staining of
the aortic arch. Induction of diabetes in ApoE -/- mice significantly promoted atherosclerotic

[HTML][HTML] From degenerative disease to malignant tumors: insight to the function of ApoE

G Miao, D Zhuo, X Han, W Yao, C Liu, H Liu… - Biomedicine & …, 2023 - Elsevier
Apolipoprotein E (ApoE) is a multifunctional protein involved in lipid transport and …
regulation play important roles in the occurrence and development of atherosclerotic diseases, …