The Outer Membrane Proteins OmpA, CarO, and OprD of Acinetobacter baumannii Confer a Two-Pronged Defense in Facilitating Its Success as a Potent Human …

SR Uppalapati, A Sett, R Pathania - Frontiers in microbiology, 2020 - frontiersin.org
proteins that induce cytotoxicity directly (eg, Type VI secretion system effector enzymes, and
toxins) or … SU, AS, and RP conceptualized the manuscript and contributed the ideas on the …

Molecular Characterization and Designing of a Novel Multiepitope Vaccine Construct Against Pseudomonas aeruginosa

J Dey, SR Mahapatra, S Patnaik, S Lata… - International Journal of …, 2022 - Springer
… of OprI and a portion of the outer membrane protein OprF [18]. … Cytotoxic T-cell (CTL),
Helper T-cell (HTL), and linear B-cell (… The protein helps in the growth of bacteria in high-osmolarity …

Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection

D Nie, Y Hu, Z Chen, M Li, Z Hou, X Luo, X Mao… - Journal of biomedical …, 2020 - Springer
… [1, 2], which leads to an increasing mortality in patients. Risk … is sufficient to exert cytotoxicity
to human laryngeal epithelial … of antibodies which kills Pseudomonas aeruginosa and A. …

Development of a novel hybrid antimicrobial peptide for targeted killing of Pseudomonas aeruginosa

H Kim, JH Jang, SC Kim, JH Cho - European Journal of Medicinal …, 2020 - Elsevier
… and serum conditions, without cytotoxicity to human cells [24]. … peptide bound to several outer
membrane proteins (OMPs). … virulence and contributing to efficient host defence against P. …

Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa

…, R Capita, C Alonso-Calleja, G Igrejas, P Poeta - International journal of …, 2021 - mdpi.com
aeruginosa’s pathogenesis, to contribute for the … system to directly inject cytotoxic effector
proteins into the cytosol of … aeruginosa PAO1 encode outer membrane proteins related to …

… novel, rationally designed, hybrid antimicrobial peptide, inspired by cathelicidin and aurein, exhibits membrane-active mechanisms against Pseudomonas aeruginosa

N Klubthawee, P Adisakwattana, W Hanpithakpong… - Scientific reports, 2020 - nature.com
… effects while reducing cytotoxicity and so overcome barriers … aeruginosa cell membranes
and accumulation in bacterial … peptide for the bacterial membrane and contribute to its strong …

Mechanism of action and resistance evasion of an antimicrobial oligomer against multidrug-resistant gram-negative bacteria

MK O'Leary, V Sundaram, JJ LiPuma… - ACS Applied Bio …, 2022 - ACS Publications
… (4) One species listed by the CDC as a serious clinical threat is MDR Pseudomonas aeruginosa.
… BDT-4G can initially evade outer membrane modifications that contribute to polymyxin …

Roles of Two-Component Systems in Pseudomonas aeruginosa Virulence

M Sultan, R Arya, KK Kim - International journal of molecular sciences, 2021 - mdpi.com
aeruginosa genes contribute to the function of type IV pili [66]. These genes encode major
structural protein PilA and other minor proteins … with pyocyanin cytotoxic effects have been …

Outer membrane vesicles (OMVs) produced by gram‐negative bacteria: structure, functions, biogenesis, and vaccine application

N Furuyama, MP Sircili - BioMed Research International, 2021 - Wiley Online Library
contribution of … proteins into host cells that confer cytotoxic activity and induce a host immune
response in intestinal epithelial cells [47, 139]. Pseudomonas aeruginosa outer membrane

Pseudomonas Aeruginosa Induced Cell Death in Acute Lung Injury and Acute Respiratory Distress Syndrome

R Deshpande, C Zou - International Journal of Molecular Sciences, 2020 - mdpi.com
… Patients with viral infection, trauma, and cancer leads to host … of epithelial cell membrane
and penetrate the membrane to … cause enhancement of epithelial cell cytotoxicity during a P. …