… A major regulator of centrosome biogenesis and function in C… protein 2 (SPD-2), a homolog
of the human CEP-192 protein. … ; the likely ortholog of Polo like kinase 4 (PLK4) in mammals …

… A major regulator of centrosome biogenesis and function in C… protein 2 (SPD-2), a homolog
of the human CEP-192 protein. … , the likely ortholog of Polo like kinase 4 (PLK4) in mammals, …

… Thus, I will emphasize centrosome biogenesis and function … recruitment of SPD-2 (orthologue
of mammalian Cep192) to … AIR-1 regulates the recruitment of microtubule-nucleating …

… In interphase, centrosomes nucleate, anchor, and regulate … during centriole and centrosome
biogenesis. Proteins localized … It is unclear how removal of Cep192 reduces centrosomal …

… and localization of CEP192 at centrosomes upon depletion of … quantity of CEP192 remained
at centrosomes in pericentrin/… cells, CEP192 localizes at the centrioles and regulates the …

… ortholog) is mediated by the coiled-coil protein Spd-2 (ortholog of the mammalian Cep192)
in the mother centriole [7,32,33]. A list of centrosomal proteins named in this review and their …

… In mammalian cells, Cep192 (SPD-2 in Drosophila) is of … Here we show that the Dictyostelium
orthologue of Cep192 is … that Cep192 is required both for centrosome biogenesis and for …

… Though the mechanisms of centrosome biogenesis and … its functional homolog in C. elegans
is SPD-5 [49]. During … at PCM, then SPD-5 and Cep192/SPD-2 gradually accumulate at the …

… level of SPD-2, a protein critical for centriole biogenesis, we … observed when cki-2, a
cdk-inhibitor ortholog was cosuppressed… in the absence of SPD-2, centrosome assembly fails. …

… with the conserved centrosome proteins Spd-2/CEP192 and Cnn/… cycle centrosomal Polo
levels peaked slightly before Spd-2 … It is becoming increasingly clear that the biogenesis of …