[HTML][HTML] Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia
RS Dos Reis, S Sant, H Keeney, MCE Wagner… - Scientific reports, 2020 - nature.com
… -induced neuropathogenesis; however, such model has not yet been explored for HIV-1
infection to … We further tested the ability of these hBORGs to support HIV-1 infection as well as to …
infection to … We further tested the ability of these hBORGs to support HIV-1 infection as well as to …
Neuropathogenesis of HIV-1: insights from across the spectrum of acute through long-term treated infection
L Killingsworth, S Spudich - Seminars in immunopathology, 2022 - Springer
… neuropathogenesis of HIV, from initial HIV entry into the central nervous system (CNS) to
chronic infection… Discoveries regarding acute HIV infection reveal timing and mechanisms of …
chronic infection… Discoveries regarding acute HIV infection reveal timing and mechanisms of …
Limited HIV-associated neuropathologies and lack of immune activation in sub-saharan African individuals with late-stage subtype C HIV-1 infection
Z Liu, P Julius, V Mudenda, G Kang, L Del Valle… - Journal of …, 2024 - Springer
… viral DNA, we focused on these two brain regions to further investigate the neuropathology
of subtype C HIV-1 infection in cases from Zambia. After HIV serological test using …
of subtype C HIV-1 infection in cases from Zambia. After HIV serological test using …
Three-dimensional human brain organoids to model HIV-1 neuropathogenesis
… pathologies similar to the HIV-1-infected individuals’ brain [6]. … organoid model to study HIV-1
neuropathogenesis, and here, we … To better recapitulate the HIV-1 infection in the brain, we …
neuropathogenesis, and here, we … To better recapitulate the HIV-1 infection in the brain, we …
Important role of microglia in HIV-1 associated neurocognitive disorders and the molecular pathways implicated in its pathogenesis
… 1 (HIV-1) infection. However, recent studies indicate that considerably more than 50% of all
HIV-1 infected patients develop HIV-1-… to neuropathogenesis during primary HIV infection by …
HIV-1 infected patients develop HIV-1-… to neuropathogenesis during primary HIV infection by …
[HTML][HTML] HIV-1 envelope protein gp120 modulation of glutamate effects on cortical neuronal synapses: implications for HIV-1-associated neuropathogenesis
… [38], indicating an involvement of NMDAR in gp120-associated neuropathophysiology. To
examine influence of gp120 on Glu in HIV-1-infected brain, we first studied individual effects of …
examine influence of gp120 on Glu in HIV-1-infected brain, we first studied individual effects of …
Opioid-mediated HIV-1 immunopathogenesis
… Among several abused drugs, the use of opiates is highly prevalent in HIV-1 infected
individuals, … , neuropathogenesis of SIV/SHIV-infected non-human primates, blood-brain-barrier, …
individuals, … , neuropathogenesis of SIV/SHIV-infected non-human primates, blood-brain-barrier, …
Neuroimaging the Neuropathogenesis of HIV
… This review highlights neuroimaging studies of HIV conducted over the last 2 years and
discusses how relevant findings further our knowledge of the neuropathology of HIV. Three …
discusses how relevant findings further our knowledge of the neuropathology of HIV. Three …
[HTML][HTML] Signatures of HIV-1 subtype B and C Tat proteins and their effects in the neuropathogenesis of HIV-associated neurocognitive impairments
… HIV-1 on the central nervous system (CNS). The HIV-1 subtypes; HIV-1 subtype B (HIV-1B)
and HIV-1 … highest prevalence of HANI and HIV infections respectively. The HIV transactivator …
and HIV-1 … highest prevalence of HANI and HIV infections respectively. The HIV transactivator …
Neuropathogenesis of HIV and emerging therapeutic targets
A Siddiqui, C He, G Lee, A Figueroa… - Expert opinion on …, 2022 - Taylor & Francis
… been recognized as consequences of HIV infection, our understanding of the mechanisms
… We discuss areas where the neuropathogenesis of HIV is relatively well-understood, such …
… We discuss areas where the neuropathogenesis of HIV is relatively well-understood, such …