[HTML][HTML] The Locus Coeruleus in Chronic Pain
JC España, A Yasoda-Mohan, S Vanneste - International Journal of …, 2024 - mdpi.com
… The main source of norepinephrine (NE) in the central nervous system is the Locus Coeruleus
… chronic pain pathways and its frequent comorbidities. The literature research showed that …
… chronic pain pathways and its frequent comorbidities. The literature research showed that …
[HTML][HTML] The role of the locus coeruleus in pain and associated stress-related disorders
I Suárez-Pereira, M Llorca-Torralba, L Bravo… - Biological …, 2022 - Elsevier
… pain generator in chronic conditions. Selective destruction of noradrenergic neurons appears
to dampen neuropathic pain … of the noradrenergic system in long-term pain. Stronger c-Fos …
to dampen neuropathic pain … of the noradrenergic system in long-term pain. Stronger c-Fos …
[HTML][HTML] Endogenous opioids gate the locus coeruleus pain generator
MR Norris, CC Kuo, JR Kim, SS Dunn, G Borges… - bioRxiv, 2023 - ncbi.nlm.nih.gov
… locus coeruleus (LC) plays a paradoxical role in chronic pain. … transform the LC into a
chronic pain generator. We sought to … locus coeruleus-noradrenergic (LC-NE) system in chronic …
chronic pain generator. We sought to … locus coeruleus-noradrenergic (LC-NE) system in chronic …
[HTML][HTML] Locus coeruleus-noradrenergic modulation of trigeminal pain: Implications for trigeminal neuralgia and psychiatric comorbidities
B Donertas-Ayaz, RM Caudle - Neurobiology of Pain, 2023 - Elsevier
… of noradrenaline in acute and chronic trigeminal pain conditions and how the activity of
the locus coeruleus noradrenergic neurons changes in response to acute and chronic pain …
the locus coeruleus noradrenergic neurons changes in response to acute and chronic pain …
Distinct brainstem to spinal cord noradrenergic pathways inversely regulate spinal neuronal activity
MW Kucharczyk, F Di Domenico, K Bannister - Brain, 2022 - academic.oup.com
… locus coeruleus on non-coerulean, discrete noradrenergic cell group(s). We implemented
locus coeruleus … the role of the locus coeruleus as a ‘chronic pain generator’. Pinpointing the …
locus coeruleus … the role of the locus coeruleus as a ‘chronic pain generator’. Pinpointing the …
Pain and depression comorbidity causes asymmetric plasticity in the locus coeruleus neurons
M Llorca-Torralba, C Camarena-Delgado… - Brain, 2022 - academic.oup.com
… pain (chronic constriction injury), we explore how this comorbidity arises. To this end, we
evaluated the time-dependent plasticity of noradrenergic locus coeruleus … in chronic pain and …
evaluated the time-dependent plasticity of noradrenergic locus coeruleus … in chronic pain and …
Pain Modulation from the Locus Coeruleus in a Model of Hydrocephalus: Searching for Oxidative Stress-Induced Noradrenergic Neuroprotection
M Louçano, J Oliveira, I Martins, R Vaz… - International Journal of …, 2022 - mdpi.com
… of AR, and the intensity and duration of the pain stimulus [22,23]. Our … pain facilitation by
showing that, in chronic pain models, NA released from the LC in the brain accounts for pain …
showing that, in chronic pain models, NA released from the LC in the brain accounts for pain …
Nerve injury induces transient locus coeruleus activation over time: role of the locus coeruleus–dorsal reticular nucleus pathway
C Camarena-Delgado, M Llorca-Torralba… - Pain, 2022 - journals.lww.com
… a source of pain inhibition but also a chronic pain generator. Furthermore, it also explains
the limited efficacy of systemic drugs increasing global noradrenaline availability. Therefore, …
the limited efficacy of systemic drugs increasing global noradrenaline availability. Therefore, …
Locus Coeruleus Integrity in Older Adults with and without Chronic Pain
… locus coeruleus integrity measured by locus coeruleus … (LC CNR ) in people with and without
chronic pain. On this scale, 0 … noradrenergic locus coeruleus as a chronic pain generator. …
chronic pain. On this scale, 0 … noradrenergic locus coeruleus as a chronic pain generator. …
Spinally projecting noradrenergic neurons of the locus coeruleus display resistance to AAV2retro-mediated transduction
RP Ganley, K Werder, H Wildner… - … Pain, 2021 - journals.sagepub.com
… However, the LC is also known to be involved in maintaining chronic pain states, 10 and
recent studies suggest that descending NA-containing projections are involved in generating …
recent studies suggest that descending NA-containing projections are involved in generating …