… The deficiency of insulin, impaired signaling, and its resistance … /PS1 mice, which overexpress
mutant forms of amyloid precursor … The 3xTg-AD mice model demonstrated brain oxidative …

… activities, and disturbed inflammatory mechanisms are the … block the production of the
amyloid-β peptide, has proven fruitless … Both, 5Xfad and 3xTg-AD mice and the human embryonic …

… of iron metabolism in the brain with the accumulation of redox-active ferrous iron in all …
treatment in 3xTg-AD mice ameliorates cognition and prevents oxidative stress, β-amyloid …

… , suggesting impairment of brain homeostatic mechanisms. … transgenic 5xFAD mice with the
human amyloid precursor … in crude membrane fractions of brain cortices of WT mice with (WT-…

… kinase-3 beta, increased amyloid beta (Aβ) accumulation, … ) fed mice induce resistance
and an impaired insulin signalling … Redox proteomics oxidizes these two proteins in the AD …

… Progressive buildup of amyloid-β peptide (Aβ), persistent … associated with AD pathology in
3xTg-AD mice [32]. SSTR4 … system in the CNS, mediated by microglia, is either impaired or …

… characterized by abnormal aggregation of amyloid β-peptide (Aβ), … Nrf2 plays a crucial role
in regulation of cellular redox … NQO1 expression in 3xTg-AD mice preceded any intraneuronal …

… Amyloid plaques in AD contain advanced glycation end-… neuroinflammatory mediators and
altered redox stress brought on … by oral gavage in 3xTG-AD mice by every 3 days for 30 days. …

… improved cognitive impairment of male and female amyloid β … and cerebral cortices of
the left hemisphere of the brain were … was expressed in the cell membrane, cytoplasm, and …

… extracellular amyloid plaques composed of the amyloid-β peptide … Knocking out miR-369 in
3xTg AD mice aggravated cognitive … Furthermore, Redox proteomics studies found that many …