[HTML][HTML] Y-box binding protein-1 promotes epithelial-mesenchymal transition in sorafenib-resistant hepatocellular carcinoma cells

LZ Liao, CT Chen, NC Li, LC Lin, BS Huang… - International journal of …, 2020 - mdpi.com
… a transcription factor, Y-box binding protein-1 (YB-1), with elevated … protein kinase B (AKT)
were activated by sorafenib, which, in turn, increased the phosphorylation level of YB-1

[HTML][HTML] Y-box binding proteins in mRNP assembly, translation, and stability control

D Mordovkina, DN Lyabin, EA Smolin, EM Sogorina… - Biomolecules, 2020 - mdpi.com
Y-box binding proteins (YB proteins) were first identified as DNA-binding proteins involved
… in various organisms [1]; their major property was thought to be the ability to bind to double-…

Role of Y-Box Binding Proteins in Ontogenesis

DA Kretov - Biochemistry (Moscow), 2022 - Springer
… on the role of YB proteins in ontogenesis, with a primary focus on data obtained in vertebrates.
Furthermore, this review discusses the functions of YB proteins in development that are …

[HTML][HTML] Y-Box-Binding Proteins Have a Dual Impact on Cellular Translation

IA Eliseeva, AI Buyan, EA Smolin… - International Journal of …, 2024 - mdpi.com
… - and RNA-binding proteins that play an important role in the … that Y-box-binding proteins may
have similar functions in a cell… interchangeability of the somatic YB proteins YB-1 and YB-3. …

Y-box binding protein 1 (YB-1) promotes gefitinib resistance in lung adenocarcinoma cells by activating AKT signaling and epithelial–mesenchymal transition through …

L Lou, J Wang, F Lv, G Wang, Y Li, L Xing, H Shen… - Cellular Oncology, 2021 - Springer
Y-box binding protein 1 (YB-1) has been reported to play a role in modulating drug sensitivity,
but its role in gefitinib … Here, we investigated the role of YB-1 in gefitinib resistance of lung …

Potential therapeutic strategies for targeting Y-Box-binding protein 1 in cancers

JW Yang, C Sun, QY Jin, XH Qiao… - Current Cancer Drug …, 2021 - ingentaconnect.com
… , Y.; Qin, Y.; Zheng, LS; [5] Zhou, JS; Qu, PH; Shi, JH; Zhang, HS The role of the Y box binding
protein 1 C… DNA Cell Biol., 2016, 35(1), 24-32; (b)Yadav, BS; Singh, S.; Shaw, AK; Mani, A. …

YB-3 substitutes YB-1 in global mRNA binding

DN Lyabin, IA Eliseeva, EA Smolin, AN Doronin… - RNA biology, 2020 - Taylor & Francis
Y-box binding proteins are DNA- and RNA-binding proteins … The Y-box binding protein
1 (YB-1) is the most studied due to … S1A), we consider that Y-box-binding proteins bind the …

[HTML][HTML] Ybox binding protein 1 acts as a negative regulator of stearoyl CoA desaturase 1 in clear cell renal cell carcinoma

E Jeffords, S Freeman, B Cole, K Root… - Oncology …, 2020 - spandidos-publications.com
Ybox binding protein 1 (YB1) is a regulatory protein … In the cell, YB1 functions as a DNA
and RNA binding protein … The cancer‑promoting activity of YB1 is mediated through its …

Structural basis of DNA binding to human YB-1 cold shock domain regulated by phosphorylation

J Zhang, JS Fan, S Li, Y Yang, P Sun… - Nucleic acids …, 2020 - academic.oup.com
… Human Y-box binding protein 1 (YB-1) is a multifunctional protein … of S102 are indispensable
for YB-1 function. Until now, the … -rich motifs (ARMs) for pleiotropic functions in RNA biology …

[HTML][HTML] YB-1 as an oncoprotein: functions, regulation, post-translational modifications, and targeted therapy

Q Yin, M Zheng, Q Luo, D Jiang, H Zhang, C Chen - Cells, 2022 - mdpi.com
Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD)
that also belongs to the family of DNA- and RNA-binding proteins. YB-1 is present in both …