A new approach of statin therapy in carotid atherosclerosis: Targeting indices of plaque vulnerability on the top of lipid-lowering. A narrative review

NPE Kadoglou, E Khattab, N Velidakis… - Polish Heart …, 2022 - journals.viamedica.pl
… use of statins in patients undergoing carotid revascularization and the impact of aggressive
vs. … on the perioperative manipulation of statins ending up with more aggressive therapy. …

Lipid-lowering therapy and hemorrhagic stroke risk: comparative meta-analysis of statins and PCSK9 inhibitors

BE Sanz-Cuesta, JL Saver - Stroke, 2021 - Am Heart Assoc
… enhancing clearance of circulating LDL. In addition, like statins they have been studied in
multiple large randomized trials providing sufficient power to characterize hemorrhagic as well …

Eradicating Atherosclerosis: Should We Start Statins at Younger Ages and at Lower LDL-Cs

T O'Toole, MD Kelsey, NP Shah, RW McGarrah… - Current cardiology …, 2022 - Springer
… : How aggressively should we lower LDL-C in younger adults, what are our treatment
strategies, and when should we start? Herein, we review the potential benefits and risks of early …

Evaluating the association between low-density lipoprotein cholesterol reduction and relative and absolute effects of statin treatment: a systematic review and meta …

P Byrne, M Demasi, M Jones, SM Smith… - JAMA internal …, 2022 - jamanetwork.com
… using this approach that there was no correlation between the annual statin mortality risk
reduction and the LDL lowering. … The aggressive lowering of LDL-C levels with treatment with …

[HTML][HTML] Relationship between low-density lipoprotein cholesterol, lipid-lowering agents and risk of stroke: a meta-analysis of observational studies (n= 355,591) and …

M Banach, N Shekoohi, DP Mikhailidis… - Archives of Medical …, 2022 - ncbi.nlm.nih.gov
… We also found no significant effect of lipid-lowering agents regardless of the types (statin
We had sufficient statistical power and a low level of type I and II error for the RCTs with regard …

Lipid lowering effects of the CETP inhibitor obicetrapib in combination with high-intensity statins: a randomized phase 2 trial

SJ Nicholls, M Ditmarsch, JJ Kastelein, SP Rigby… - Nature medicine, 2022 - nature.com
… include aggressive goals for low-density lipoprotein cholesterol (LDL-C). Statin therapy …
to provide more than 90% power to detect a 30% difference in LDL-C reduction at week 8 (…

The role of statins in current guidelines

F Rached, RD Santos - Current atherosclerosis reports, 2020 - Springer
… 2 years while on maximally tolerated statin therapy, an even more aggressive goal of LDL-C
< 40 mg/… Impact of renal function on the effects of LDL cholesterol lowering with statin-based …

[HTML][HTML] Intensive lipid-lowering therapy, time to think beyond low-density lipoprotein cholesterol

A Abdalwahab, A Al-Atta, A Zaman… - World Journal of …, 2021 - ncbi.nlm.nih.gov
… vascular disease and LDL-c should be targeted using statin alongside non-statin drugs. …
and aggressive atherosclerotic disease and, therefore, intensive lipid lowering therapy had …

Use of lipid-lowering drugs after intracerebral hemorrhage

A Shoamanesh, M Selim - Stroke, 2022 - Am Heart Assoc
… Apart from the potential for limited power to detect a … Despite the aggressive reductions in
LDL-C levels induced with … favor avoiding statins and using alternative lipid-lowering treatments…

Meta‐analysis of intensive lipidlowering therapy in patients with polyvascular disease

M Alkhalil, M Kuzemczak, N Whitehead… - Journal of the …, 2021 - Am Heart Assoc
… intensive lipidlowering strategy of the original studies as previously described. Therefore,
the intensity of statin … , the statin arms were included in the intensive lipidlowering group. , 15 …